Radio-Frequency Catheter Ablation for Treatment of Atrial Fibrillation: The Influence of Probe Contact on Impedance and Lesion Formation
| atmire.migration.oldid | 416 | |
| dc.contributor.advisor | Vigmond, Edward | |
| dc.contributor.advisor | Fear, Elise | |
| dc.contributor.author | Gallagher, Neal | |
| dc.date.accessioned | 2012-10-01T18:39:03Z | |
| dc.date.available | 2012-11-13T08:01:45Z | |
| dc.date.issued | 2012-10-01 | |
| dc.date.submitted | 2012 | en |
| dc.description.abstract | Radio-Frequency (RF) catheter ablation is a promising, minimally invasive treatment modality in the battle against the most prevalent cardiac arrhythmia, Atrial Fibrillation (AF). While it is known that catheter contact affects the size and shape of lesions produced during an ablation procedure, little has been done to quantify this effect. The purpose of this research was to establish a framework to determine the relationship between contact and lesion formation, and how contact can be assessed using electrical impedance. First, an electroquasistatic computer model was created to approximate the Left Atrium (LA) and the complex impedance was calculated. It was found that impedance varies in proportion to catheter contact area; not just to penetration depth as popularly thought. Finally, a thermal model was implemented. It was found that angle can significantly affect lesion sizes. Interestingly, lesion formation rates were highly dependent on catheter contact area while the transient response of the maximum temperature detected in the tissue was more dependent on catheter penetration depth. Clinically, these discoveries are a step towards understanding the electrical and thermal behaviours that are inherent in cardiac ablation. | en_US |
| dc.identifier.citation | Gallagher, N. (2012). Radio-Frequency Catheter Ablation for Treatment of Atrial Fibrillation: The Influence of Probe Contact on Impedance and Lesion Formation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27520 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/27520 | |
| dc.identifier.uri | http://hdl.handle.net/11023/251 | |
| dc.language.iso | eng | |
| dc.publisher.faculty | Graduate Studies | |
| dc.publisher.institution | University of Calgary | en |
| dc.publisher.place | Calgary | en |
| dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | |
| dc.subject | Electricity and Magnetism | |
| dc.subject | Engineering--Biomedical | |
| dc.subject | Engineering--Electronics and Electrical | |
| dc.subject.classification | Catheter Ablation | en_US |
| dc.subject.classification | Atrial Fibrillation | en_US |
| dc.subject.classification | Electrothermal Modelling | en_US |
| dc.subject.classification | Biophysical Modelling | en_US |
| dc.title | Radio-Frequency Catheter Ablation for Treatment of Atrial Fibrillation: The Influence of Probe Contact on Impedance and Lesion Formation | |
| dc.type | master thesis | |
| thesis.degree.discipline | Electrical and Computer Engineering | |
| thesis.degree.grantor | University of Calgary | |
| thesis.degree.name | Master of Science (MSc) | |
| ucalgary.item.requestcopy | true |