pyCellAnalyst: Extensive Software for Three-dimensional Analysis of Deforming Cells

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atmire.migration.oldid4358
dc.contributor.advisorHerzog, Walter
dc.contributor.advisorFederico, Salvatore
dc.contributor.authorSibole, Scott C.
dc.contributor.committeememberEpstein, Marcelo
dc.contributor.committeememberEdwards, Brent
dc.contributor.committeememberBoyd, Steven
dc.contributor.committeememberAlim, Usman
dc.date.accessioned2016-05-04T18:19:12Z
dc.date.available2016-05-04T18:19:12Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractLaser scanning microscopy has proven to be a transformative tool in the biomedical sciences. The technology provides a means to image three-dimensional, time-varying, micro-scale features within living tissue, which in turn has borne exciting avenues for the experimental investigation of the relationship between the hierarchical spatial scales within organisms. By coupling laser scanning microscopes to mechanical testing systems, one can study the relationships between mechanics at the organ, tissue, and cellular scales. In practice, while a controlled mechanical state is applied to intact tissue, images of the cells within can be obtained via microscopy; however, extracting the geometric information from these images and characterizing deformation has been a challenge to the field. pyCellAnalyst is an extensive software framework for such analysis of these image data. It provides an accessible interface to reconstruct cellular geometries from images, characterize deformation, and perform finite element analyses informed by the experimental observations.en_US
dc.identifier.citationSibole, S. C. (2016). pyCellAnalyst: Extensive Software for Three-dimensional Analysis of Deforming Cells (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27488en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27488
dc.identifier.urihttp://hdl.handle.net/11023/2966
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultySchulich School of Engineering
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectComputer Science
dc.subjectEngineering--Biomedical
dc.subjectEngineering--Mechanical
dc.subject.classificationMicroscopyen_US
dc.subject.classificationChondrocyteen_US
dc.subject.classificationImage Processingen_US
dc.subject.classificationMultiscaleen_US
dc.subject.classificationFinite Elementen_US
dc.subject.classificationImage Segmentationen_US
dc.subject.classificationContinuum Mechanicsen_US
dc.subject.classificationArticular cartilageen_US
dc.titlepyCellAnalyst: Extensive Software for Three-dimensional Analysis of Deforming Cells
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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