Population dynamics and adaptation of pseudomonas aeruginose during chronic lung infection in cystic fibrosis

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dc.contributor.advisorSurette, Michael G.
dc.contributor.authorNorgaard-Gron, Jens Christian
dc.date.accessioned2017-12-18T22:05:57Z
dc.date.available2017-12-18T22:05:57Z
dc.date.issued2010
dc.descriptionBibliography: p. 147-174en
dc.descriptionSome pages are in colour.en
dc.description.abstractPseudomonas aeruginosa is the most frequently isolated organism from patients with cystic fibrosis. Colonization occurs in early childhood and persists throughout the lifetime of patients. During chronic airway infection, P. aeruginosa is generally thought to evolve into a chronic phenotype characterized by acquisition of a number of mutations that results in loss of virulence factors required for acute infection. However, P. aeruginosa cultured from sputum exhibits a wide range of colony morphologies and suggests that P. aeruginosa in chronic airway infection has an unexplored level of diversity. To examine the population dynamics of P. aeruginosa in CF airways, we monitored morphotypes isolated during periods of pulmonary exacerbation in four CF adult patients with quantitative and quantitative microbiology. Phenotypic profiling was carried out for P. aeruginosa virulence factors generally considered to be lost during chronic infection. Results from this study indicate that P. aeruginosa CF population is highly diverse and virulence factors are still present in chronic infection.
dc.format.extentix, 217 leaves : ill. ; 30 cm.en
dc.identifier.citationNorgaard-Gron, J. C. (2010). Population dynamics and adaptation of pseudomonas aeruginose during chronic lung infection in cystic fibrosis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/3428en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/3428
dc.identifier.urihttp://hdl.handle.net/1880/104429
dc.language.isoeng
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titlePopulation dynamics and adaptation of pseudomonas aeruginose during chronic lung infection in cystic fibrosis
dc.typemaster thesis
thesis.degree.disciplineMicrobiology & Infectious Diseases
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 1954 627942797
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
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