Shape Memory Alloy-based Whole Blood Glucose Monitoring Device: The e-Mosquito

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atmire.migration.oldid6185
dc.contributor.advisorMintchev, Martin
dc.contributor.advisorYadid-Pecht, Orly
dc.contributor.authorWang, Gang
dc.contributor.committeememberSmith, Michael
dc.contributor.committeememberYanushkevich, Svetlana
dc.contributor.committeememberMurari, Kartikeya
dc.contributor.committeememberGavrilova, Marina
dc.contributor.committeememberKaminska, Bozena
dc.date.accessioned2017-11-22T17:27:14Z
dc.date.available2017-11-22T17:27:14Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractDiabetes Mellitus (DM) is a systemic disorder that results in elevated blood glucose levels in the body, leading to many secondary complications. Presently, manual fingerpicking tests remain the most popular method of blood glucose monitoring (BGM). However, the tests are often ignored by DM patients due to the pain and inconvenience. This thesis aims at addressing a growing demand for replacing the fingerpricking tests by presenting a wearable microsystem for minimally invasive, autonomous and pseudo-continuous blood glucose monitoring, the e-Mosquito. The proposed design of the e-Mosquito device aims to extract whole blood sample from a small lanced skin wound using a novel shape memory alloy (SMA)-based microactuator and directly measure the blood glucose level from this sample. A completely functional prototype of the e-Mosquito was developed. The prototype was first tested in-vitro on a custom-designed mechanical test station. Measurements showed that the output force and depth met the minimum requirements for reaching subcutaneous blood capillaries. The microactuation mechanism was also evaluated by extracting blood samples from the wrist of four human volunteers. 19 out of 23 actuations successfully reached capillary vessels below the wrist producing blood droplets on the surface of the skin. The integrated potentiostat-based glucose sensing circuit of the e-Mosquito device also showed a good linear correlation (R^2=0.9733) with measurements using standard BGM technology. These proof-of-concept studies demonstrated the feasibility of the SMA-based e-Mosquito device for replacing the fingerpricking tests in DM management.en_US
dc.identifier.citationWang, G. (2017). Shape Memory Alloy-based Whole Blood Glucose Monitoring Device: The e-Mosquito (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27771en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27771
dc.identifier.urihttp://hdl.handle.net/11023/4250
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEngineering--Biomedical
dc.subjectEngineering--Electronics and Electrical
dc.subject.otherBlood Glucose Monitoring
dc.subject.otherShape Memory Alloy
dc.subject.otherWearable Device
dc.subject.otherdiabetes
dc.titleShape Memory Alloy-based Whole Blood Glucose Monitoring Device: The e-Mosquito
dc.typedoctoral thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameDoctor of Philosophy (PhD)
ucalgary.item.requestcopytrue
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