Functional Connectivity of the Anterior Cingulate Cortex in Children with Post-traumatic Headache

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dc.contributor.advisorBarlow, Karen Maria
dc.contributor.advisorDewey, Deborah
dc.contributor.authorOfoghi, Zahra
dc.contributor.committeememberYeates, Keith Owen
dc.contributor.committeememberBray, Signe L.
dc.contributor.committeememberNoel, Melanie
dc.date2020-05-06
dc.date.accessioned2020-05-22T22:43:57Z
dc.date.available2020-05-22T22:43:57Z
dc.date.issued2020-05-19
dc.description.abstractPost-traumatic headache (PTH) is among the most common persistent post-concussion symptoms following mild traumatic brain injury (mTBI). Investigating structural and functional neuroimaging correlates of pain or headache can help to understand biological mechanisms behind persistent PTH. In this dissertation, a systematic review was conducted to examine the neuroimaging correlates of headache or pain following mTBI. Here, in the adult populations with PTH, there was evidence to suggest alterations in descending pain modulatory mechanisms but there was a lack of research in the pediatric populations with PTH. The remainder of this thesis addresses this knowledge gap by investigating alterations in central pain processing networks with a focus on the anterior cingulate cortex (ACC). To do this, functional connectivity (FC) between the ACC and other pain-related regions was explored in children with PTH and compared to those without PTH following mTBI and uninjured healthy controls. The influence of a pre-injury headache history on ACC FC was then investigated. As other cognitive and affective symptoms are also common in children with PTH, the associations between attention problems and anxiety and ACC FC were studied. Functional connectivity of the perigenual ACC-cerebellum and the subgenual ACC-DLPFC were different in children with PTH compared to healthy controls. No significant differences, however, were found in children with and without PTH. Functional connectivity between the ventral ACC areas (rostral and perigenual) and cerebellum was significantly affected by a past history of headache problems; children with PTH and a history of headache having decreased negative FC. In children with PTH, better attention performance was associated with stronger subgenual ACC-cerebellum FC. Anxiety, however, was not associated with the ACC FC and pain-related regions. Taken together, this dissertation provides evidence of alterations in descending modulatory pain processing mechanisms in children with PTH following mTBI. Further, for the first time, neuroimaging evidence supported the effect of pre-injury headaches on connectivity between pain-related regions in children with PTH. Future studies should explore FC of other pain-related regions (e.g. periaqueductal regions, cerebellum) in central pain processing networks and their relationship with recovery.en_US
dc.identifier.citationOfoghi, Z. (2020). Functional Connectivity of the Anterior Cingulate Cortex in Children with Post-traumatic Headache (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/37875
dc.identifier.urihttp://hdl.handle.net/1880/112114
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectmild traumatic brain injuryen_US
dc.subjectpost-traumatic headacheen_US
dc.subjectpainen_US
dc.subjectheadacheen_US
dc.subjectfMRIen_US
dc.subjectresting-stateen_US
dc.subjectfunctional connectivityen_US
dc.subjectAnterior cingulate cortexen_US
dc.subject.classificationEducation--Healthen_US
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationMental Healthen_US
dc.subject.classificationPsychologyen_US
dc.subject.classificationPsychology--Clinicalen_US
dc.subject.classificationPsychology--Cognitiveen_US
dc.subject.classificationPsychobiologyen_US
dc.titleFunctional Connectivity of the Anterior Cingulate Cortex in Children with Post-traumatic Headacheen_US
dc.typedoctoral thesisen_US
thesis.degree.disciplineMedicine – Neuroscienceen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameDoctor of Philosophy (PhD)en_US
ucalgary.item.requestcopyfalseen_US
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