Impact of insulin or incretin hormones in reversing diabetic neuropathy in type 1 and type 2 diabetes mellitus

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dc.contributor.advisorZochodne, Douglas
dc.contributor.authorKan, Michelle
dc.date.accessioned2017-12-18T22:20:19Z
dc.date.available2017-12-18T22:20:19Z
dc.date.issued2011
dc.descriptionBibliography: p. 125-138en
dc.descriptionA few pages are in colour.en
dc.description.abstractDiabetes mellitus is a metabolic disorder where long-term complications including neuropathy, or nerve damage may arise. Peripheral neuropathy affects approximately 50% of total diabetic patients. Diabetic peripheral neuropathy (DPN) is a length-dependent sensorimotor nerve disorder that can lead to pain, loss of feeling and motor ability. In this work we sought to determine whether insulin or exendin-4 will serve as neurotrophic and neuroprotective factors in both type 1 and type 2 diabetes and reverse DPN pathology. Our results showed that insulin or exendin-4 treatment improved some features of neuropathy in type 1 but not type 2 diabetes. Furthermore, a full reversal of DPN was not observed showing that current clinical dosing of insulin or exendin-4 therapy does not benefit neuropathy.en
dc.format.extentxiii, 138 leaves : ill. ; 30 cm.en
dc.identifier.citationKan, M. (2011). Impact of insulin or incretin hormones in reversing diabetic neuropathy in type 1 and type 2 diabetes mellitus (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4182en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/4182
dc.identifier.urihttp://hdl.handle.net/1880/105183
dc.language.isoeng
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titleImpact of insulin or incretin hormones in reversing diabetic neuropathy in type 1 and type 2 diabetes mellitus
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 2019 627942869
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
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