The effects of maternal immune activation on the behaviour of mice lacking vesicular zinc

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dc.contributor.advisorDyck, Richard H.
dc.contributor.authorSandoval, Katy Celina
dc.contributor.committeememberAntle, Michael C.
dc.contributor.committeememberSargin, Derya
dc.contributor.committeememberGuo, Jiami
dc.date2020-11
dc.date.accessioned2020-09-17T14:37:45Z
dc.date.available2020-09-17T14:37:45Z
dc.date.issued2020-09-15
dc.description.abstractZinc is an important part of the structure and functioning of the brain. It helps in the development of neurons and synaptic connections as well as neural transmission. Within the brain, zinc transporter 3 (ZnT3) is important for the uptake of zinc into vesicles. Loss of vesicular zinc has been shown to produce neurodevelopmental disorder-like behaviour, such as decreased social interaction, and increased anxiety- and repetitive-like behaviour. We were interested in assessing the effects of maternal immune activation (MIA) on the behaviour of mice lacking vesicular zinc. MIA has been identified as an environmental factor for neurodevelopmental disorders, such as autism spectrum disorders (ASDs) and schizophrenia (SZ), in offspring, which occurs during pregnancy when the mother’s immune system reacts to the exposure to viruses or infectious diseases. To evaluate the interaction effect of a genetic factor (ZnT3 knockout (KO) mice) and environmental factor (MIA induced polyI:C), we expected to observe an increased susceptibility of developing ASD- and SZ-like phenotype in ZnT3 KO MIA-offspring. We hypothesized that this phenotype would be more severe in ZnT3 KO, and more severe in male ZnT3 KO MIA-offspring than female mice. MIA induction during gestation showed ASD- and SZ-like phenotype only in certain behavioural tests. ZnT3 KO mice did not show enhanced ASD- and SZ-like phenotype compared to WT mice. The behavioural phenotype was more significant in male mice than female offspring. These results suggest that loss of vesicular zinc does not increase susceptibility to develop ASD- and SZ-like features in the behaviours examined here.en_US
dc.identifier.citationSandoval, K. C. (2020). The effects of maternal immune activation on the behaviour of mice lacking vesicular zinc (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38208
dc.identifier.urihttp://hdl.handle.net/1880/112543
dc.language.isoengen_US
dc.publisher.facultyArtsen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectzincen_US
dc.subjectmaternal immune activationen_US
dc.subjectZnT3en_US
dc.subjectpolyI:Cen_US
dc.subjectvesicular zincen_US
dc.subjectmiceen_US
dc.subjectautism spectrum disordersen_US
dc.subjectschizophreniaen_US
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationPsychology--Behavioralen_US
dc.subject.classificationPsychology--Developmentalen_US
dc.titleThe effects of maternal immune activation on the behaviour of mice lacking vesicular zincen_US
dc.typemaster thesisen_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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