Needle and Potentiostat Study for Blood Glucose Monitoring: Third-Generation E-Mosquito

Teixeira de Carvalho Rojas, Jonas

Needle and Potentiostat Study for Blood Glucose Monitoring: Third-Generation E-Mosquito

dc.contributor.advisor	Mintchev, Martin P.
dc.contributor.advisor	Yadid-Pecht, Orly
dc.contributor.author	Teixeira de Carvalho Rojas, Jonas
dc.contributor.committeemember	Nielsen, Jorgen
dc.contributor.committeemember	Curiel, Laura
dc.contributor.committeemember	Smith, Michael Richard
dc.date	2020-06
dc.date.accessioned	2020-03-06T16:33:40Z
dc.date.available	2020-03-06T16:33:40Z
dc.date.issued	2020-03-04
dc.description.abstract	Diabetes Mellitus is a lifelong condition related to the inability of the pancreas to produce insulin, a hormone that regulates glucose levels in the body. Diabetes can also occur when the body resists the effects of the insulin. If diabetes is not treated properly or in time, the consequences can be severe and will put the patient’s life at risk. To control the glucose levels in their body, patients perform self-managed treatments. The objective of these treatments is to normalize the glucose levels by continuously monitoring the blood. Due to their high-accuracy in displaying real-time glucose concentration in the blood, finger pricking tests have become the most popular method to monitor the glucose levels. However, the finger prick method remains inconvenient for the patient. This is due to the technique, which demands the user to stab themself with a needle (inflicting pain) to access a blood sample. As a consequence, a significant number of patients drop their treatments. E-Mosquito is a new concept: a minimally-invasive glucose monitor meant to replace the finger pricking test. The second-generation E-Mosquito has proven to be an effective device to access a blood sample without inflicting pain to the user. Additionally, the E-Mosquito also has a glucometer that matches the accuracy of its commercial counterparts. Nevertheless, the E-Mosquito still requires some adjustments to acquire the correct amount of blood with a high success rate. The glucometer also requires improvement to avoid noise insertion in the circuit, that could influence the glucose readings. This thesis aims to optimize the E-Mosquito’s efficiency with two different studies. The first study focuses on selecting an appropriate needle to increase the success rate and the amount of blood acquired from the patient without inflicting pain. Furthermore, changes in the E-Mosquito design were performed to adjust the SMA actuator used in the blood acquisition. The second study is the addition of a new programmable electrochemical potentiostat. This addition reduces the number of components integrating the glucometer and maximize the accuracy of the glucose detection in the E-Mosquito when evaluating a blood sample. In the needle study, six out of eight tests extracted the required amount of blood, meaning that the success rate increased 25% for blood samples <10µL. The electrochemical potentiostat study shows that the new chip reduces the number of components inside the E-Mosquito, from three to just one, without affecting its accuracy. The glucometer exhibited a good linear correlation (R=0.9728). This complies with the standards set by the Food and Drug Administration. The two studies increase the feasibility of the E-Mosquito to replace the current glucose monitor devices.	en_US
dc.identifier.citation	Teixeira de Carvalho Rojas, J. (2020). Needle and Potentiostat Study for Blood Glucose Monitoring: Third-Generation E-Mosquito (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.	en_US
dc.identifier.doi	http://dx.doi.org/10.11575/PRISM/37628
dc.identifier.uri	http://hdl.handle.net/1880/111718
dc.language.iso	eng	en_US
dc.publisher.faculty	Schulich School of Engineering	en_US
dc.publisher.institution	University of Calgary	en
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.	en_US
dc.subject	E-Mosquito	en_US
dc.subject	BGM	en_US
dc.subject	Glucose	en_US
dc.subject	Diabetes	en_US
dc.subject.classification	Education--Health	en_US
dc.subject.classification	Education--Sciences	en_US
dc.subject.classification	Education--Technology	en_US
dc.subject.classification	Biophysics--Medical	en_US
dc.subject.classification	Engineering--Biomedical	en_US
dc.subject.classification	Engineering--Electronics and Electrical	en_US
dc.subject.classification	Engineering--Mechanical	en_US
dc.title	Needle and Potentiostat Study for Blood Glucose Monitoring: Third-Generation E-Mosquito	en_US
dc.type	master thesis	en_US
thesis.degree.discipline	Engineering – Electrical & Computer	en_US
thesis.degree.grantor	University of Calgary	en_US
thesis.degree.name	Master of Science (MSc)	en_US
ucalgary.item.requestcopy	true	en_US