Examining the Relationship Between Obsessive-Compulsive Symptoms, Genetic Risk and Cortical Thickness in Youth

Corrigan, Kimberly

Examining the Relationship Between Obsessive-Compulsive Symptoms, Genetic Risk and Cortical Thickness in Youth

dc.contributor.advisor	Arnold, Paul Daniel
dc.contributor.advisor	MacMaster, Frank P.
dc.contributor.author	Corrigan, Kimberly
dc.contributor.committeemember	Harris, Ashley D.
dc.contributor.committeemember	Dimitropoulos, Gina
dc.date	2019-11
dc.date.accessioned	2019-09-06T20:26:43Z
dc.date.available	2019-09-06T20:26:43Z
dc.date.issued	2019-09-04
dc.description.abstract	Obsessive-compulsive disorder (OCD) is a disabling neuropsychiatric disorder that affects approximately 1-3% of the population worldwide. One-third to one-half of individuals with OCD have symptom onset before 15 years of age. The heterogeneous clinical expression of OCD has rendered inconsistent findings from structural imaging studies with small sample sizes. Large scale structural imaging studies are needed to better understand the complicated neurobiology of OCD in child and adolescent population. To assess brain structure, magnetic resonance imaging (MRI) was used. FreeSurfer (Version 6.0) recon-all pathway was used to determine cortical thickness. The cingulate cortex, orbitofrontal cortex and insular cortex were selected as regions of interest. A candidate gene analysis of PTPRD SNP rs7856850 was performed using Illumina Multi-Ethnic Global microarray. Obsessive-compulsive symptom severity was determined using the Child Behaviour Checklist Obsessive-Compulsive Scale (CBCL-OCS). A significant relationship was found between the current CBCL-OCS score and the right posterior cingulate. Increase in symptom severity on the current CBCL-OCS predicted an increase in cortical thickness of the right posterior cingulate. Rs7856850 genotype did not significantly modify the relationship between symptom severity and right posterior cingulate thickness. This a unique large scale pediatric imaging study investigating the association between obsessive-compulsive symptoms and cortical thickness with an additional exploration of a PTPRD SNP variant. The results support the concept that the posterior cingulate is involved in the pathophysiology of OCD. The candidate gene analysis was inconclusive but hopefully, this study will encourage more research in the neurobiology of youth OCD.	en_US
dc.identifier.citation	Corrigan, K. (2019). Examining the Relationship Between Obsessive-Compulsive Symptoms, Genetic Risk and Cortical Thickness in Youth (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.	en_US
dc.identifier.doi	http://dx.doi.org/10.11575/PRISM/36950
dc.identifier.uri	http://hdl.handle.net/1880/110872
dc.language.iso	eng	en_US
dc.publisher.faculty	Cumming School of Medicine	en_US
dc.publisher.institution	University of Calgary	en
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.	en_US
dc.subject	child; adolescent; youth; obsessive-compulsive; neuroimaging, cortical thickness, candidate gene; PTPRD	en_US
dc.subject.classification	Genetics	en_US
dc.subject.classification	Neuroscience	en_US
dc.subject.classification	Mental Health	en_US
dc.title	Examining the Relationship Between Obsessive-Compulsive Symptoms, Genetic Risk and Cortical Thickness in Youth	en_US
dc.type	master thesis	en_US
thesis.degree.discipline	Medicine – Medical Sciences	en_US
thesis.degree.grantor	University of Calgary	en_US
thesis.degree.name	Master of Science (MSc)	en_US
ucalgary.item.requestcopy	true	en_US