Mechanisms of Neurogenesis-Mediated Forgetting in the Hippocampus

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dc.contributor.advisorEpp, Jonathan Richard
dc.contributor.authorEvans, Alexandria
dc.contributor.committeememberDyck, Richard H.
dc.contributor.committeememberTeskey, Gordon Campbell
dc.date2021-02
dc.date.accessioned2021-01-05T19:44:40Z
dc.date.available2021-01-05T19:44:40Z
dc.date.issued2020-12-18
dc.description.abstractThe mammalian hippocampus is an area of the brain responsible for learning and memory, and one of the few regions where neurogenesis continues throughout life (Altman, 1962). Neurogenesis in the dentate gyrus (DG) of the hippocampus has a role in many essential learning and memory processes, including forgetting (Akers et al., 2014). This forgetting process is important because it prevents proactive interference between old and new memories (Epp et al., 2016). However, the DG is not typically thought of as the place where new memories are stored; therefore, this process is likely occurring downstream of the DG. While several studies have examined the modulation of neurogenesis in forgetting behaviour, little research has investigated how this process is occurring within the hippocampus. Thus, the main goal of my thesis was to identify subregions of the hippocampus that play a role in this forgetting mechanism by (1) quantifying c-Fos expression in hippocampal subregions and the entorhinal cortex (EC) following a contextual conditioning task in mice and (2) monitoring real-time neuronal activity during the contextual task using fiber photometry. We replicated previous findings by others, confirming that increasing neurogenesis enhances forgetting. We found that voluntary running, to the extent that neurogenesis is increased, results in decreased context memory and decreased activity in CA1 and the supragranular and infragranular layers of the EC.en_US
dc.identifier.citationEvans, A. (2020). Mechanisms of Neurogenesis-Mediated Forgetting in the Hippocampus (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38507
dc.identifier.urihttp://hdl.handle.net/1880/112915
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectadult neurogenesisen_US
dc.subjectforgettingen_US
dc.subjectCA1en_US
dc.subjectc-Fosen_US
dc.subjectfiber photometryen_US
dc.subjecthippocampusen_US
dc.subjectmemoryen_US
dc.subject.classificationNeuroscienceen_US
dc.titleMechanisms of Neurogenesis-Mediated Forgetting in the Hippocampusen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Neuroscienceen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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