An Economic Evaluation of the Syncope: Pacing or Recording in the Later Years (SPRITELY) Trial

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dc.contributor.advisorClement, Fiona M.
dc.contributor.authorHofmeister, Mark Ronald
dc.contributor.committeememberSpackman, David Eldon
dc.contributor.committeememberSheldon, Robert S.
dc.date2018-11
dc.date.accessioned2018-07-11T16:50:59Z
dc.date.available2018-07-11T16:50:59Z
dc.date.issued2018-07-06
dc.description.abstractThe Syncope: Pacing or Recording In ThE Later Years (SPRITELY) trial tests the hypothesis that pacemaker insertion in patients with syncope, bifascicular block, and age greater than 50 years prevents syncope recurrences and major clinical events more effectively than therapy guided by monitoring with an implantable loop recorder. Equipoise or uncertainty reflected in guidelines and recommendations for both strategies may contribute to variation in management and inefficient resource use. Clinical analysis of the SPRITELY trial is complemented with an economic evaluation. The goal of this thesis was to establish the relative cost-effectiveness of the implantable loop recorder and the pacemaker in patients with bifascicular block, unexplained syncope, and age greater than 50 years. An economic evaluation of the SPRITELY trial was conducted to match the prespecified time horizon of two years for the clinical analysis (Chapter 3), and a decision analytic model was built to extend the time horizon to three years to match clinical practice (Chapter 4). In Chapter 5, the effect of taking three different national perspectives for the SPRITELY trial evaluation was explored. This thesis ends with a discussion and conclusions in Chapter 6.en_US
dc.identifier.citationHofmeister, M. R. (2018). An Economic Evaluation of the Syncope: Pacing or Recording in the Later Years (SPRITELY) Trial (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/32351en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/32351
dc.identifier.urihttp://hdl.handle.net/1880/107129
dc.language.isoeng
dc.publisher.facultyCumming School of Medicine
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectHealth Economics
dc.subjectBifascicular block
dc.subjectSyncope
dc.subjectPacemaker
dc.subjectImplantable loop recorder
dc.subject.classificationHealth Sciencesen_US
dc.titleAn Economic Evaluation of the Syncope: Pacing or Recording in the Later Years (SPRITELY) Trial
dc.typemaster thesis
thesis.degree.disciplineCommunity Health Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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