Identifying the Neuropsychological Profile of Cerebral Amyloid Angiopathy

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atmire.migration.oldid3384
dc.contributor.advisorSmith, Eric
dc.contributor.authorCase, Nevicia
dc.date.accessioned2015-07-13T15:26:05Z
dc.date.available2015-11-20T08:00:27Z
dc.date.issued2015-07-13
dc.date.submitted2015en
dc.description.abstractCerebral amyloid angiopathy (CAA) occurs when the protein, beta-amyloid, deposits onto blood vessels in the brain, often resulting in cognitive impairment. This study aims to identify the neuropsychological profile of CAA by comparing CAA participants to the normal population and cognitively-similar patient populations, distinguishing between CAA syndromes, and determining whether white matter hyperintensity volume or APOE ε4 mediate cognitive impairment. Thirty-four CAA, 16 Alzheimer’s disease, 69 mild cognitive impairment, and 27 minor ischemic stroke participants underwent neuropsychological testing. Cross-sectional data revealed lower performance on tests of perceptual speed, episodic memory, and executive functioning in CAA participants when compared to the normal population (t(33) = -3.76, p = <0.001; t(32) = -2.45, p = 0.02; t(33) = -6.21, p = <0.001; respectively). Overall, CAA was most cognitively similar to vascular cognitive impairment. Larger sample sizes and longitudinal analyses in future will help to advance understanding of cognitive deficits associated with CAA.en_US
dc.identifier.citationCase, N. (2015). Identifying the Neuropsychological Profile of Cerebral Amyloid Angiopathy (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26436en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26436
dc.identifier.urihttp://hdl.handle.net/11023/2350
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectMental Health
dc.subjectPsychology--Cognitive
dc.subject.classificationCerebral Amyloid Angiopathyen_US
dc.subject.classificationAlzheimer's Diseaseen_US
dc.subject.classificationvascular cognitive impairmenten_US
dc.subject.classificationwhite matter hyperintensitiesen_US
dc.subject.classificationStrokeen_US
dc.subject.classificationbeta-amyloiden_US
dc.titleIdentifying the Neuropsychological Profile of Cerebral Amyloid Angiopathy
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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