Corticospinal Tract Diffusion Tensor Imaging and Motor Function in Children following Perinatal Stroke

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atmire.migration.oldid560
dc.contributor.advisorKirton, Adam
dc.contributor.advisorGoodyear, Bradley
dc.contributor.authorHodge, Jacquelyn
dc.date.accessioned2013-01-08T17:45:25Z
dc.date.available2013-06-15T07:01:42Z
dc.date.issued2013-01-08
dc.date.submitted2013en
dc.description.abstractPerinatal stroke causes most hemiplegic cerebral palsy. Understanding developmental motor plasticity after perinatal injury is key to developing new therapies. Diffusion tensor imaging (DTI) facilitates this by interrogating functional white matter tracts (e.g. corticospinal tract, CST) but is not well studied in perinatal stroke. Our aim was to quantify CST integrity following perinatal stroke with DTI, evaluating different methodologies and correlations to motor outcome. Twenty-six children (Alberta Perinatal Stroke Project) underwent standardized DTI. Fiber tracking across different CST sections and ROI analysis compared CST diffusion variable (FA/AD/RD/MD) ratios (lesioned/non-lesioned). Correlations with validated motor outcome measures (AHA, MA, PSOM) were sought. DTI quantified differences in all CST diffusion parameters. Decreased FA and increased RD in the lesioned CST demonstrated the most robust correlations with motor outcomes. Analysis of defined CST subtracts may offer advantages over traditional DTI techniques. CST DTI carries both clinical and research utility in perinatal stroke.en_US
dc.identifier.citationHodge, J. (2013). Corticospinal Tract Diffusion Tensor Imaging and Motor Function in Children following Perinatal Stroke (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25473en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25473
dc.identifier.urihttp://hdl.handle.net/11023/397
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectHealth Sciences
dc.subject.classificationperinatal strokeen_US
dc.subject.classificationDiffusion Tensor Imagingen_US
dc.subject.classificationMotor Functionen_US
dc.titleCorticospinal Tract Diffusion Tensor Imaging and Motor Function in Children following Perinatal Stroke
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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