Neuroimaging Biomarkers of Alzheimer’s Disease and Cerebrovascular Disease in Patients with Subjective Cognitive Concerns and Mild Cognitive Impairment

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atmire.migration.oldid3515
dc.contributor.advisorSmith, Eric
dc.contributor.advisorFrayne, Richard
dc.contributor.authorWang, Xinjue Rachel
dc.date.accessioned2015-09-02T14:18:27Z
dc.date.available2015-11-20T08:00:38Z
dc.date.issued2015-09-02
dc.date.submitted2015en
dc.description.abstractIn these studies, patients with subjective cognitive concerns (SCC; n = 43) and mild cognitive impairment (MCI; n = 18), were compared using neuroimaging biomarkers for β-amyloid, white matter hyperintensities (WMH) of presumed vascular origin, and cerebral perfusion. Higher WMH burden was found in SCC compared to MCI (p = 0.02). In the whole cohort, there was a correlation between higher β-amyloid accumulation and lower left (p = 0.02) and right temporal gyrus perfusion (p = 0.05), while higher WMH burden was associated with lower perfusion in the cortical grey matter (p = 0.01), posterior cingulate cortex (p = 0.02) and right temporal gyrus (p = 0.01). Exploratory comparisons suggested lower perfusion in the left temporal gyrus and anterior cingulate cortex in amnestic MCI (n = 12) compared to non-amnestic MCI (n = 6). These findings suggest that pathologies consistent with dementia are evident in early cognitive decline.en_US
dc.identifier.citationWang, X. R. (2015). Neuroimaging Biomarkers of Alzheimer’s Disease and Cerebrovascular Disease in Patients with Subjective Cognitive Concerns and Mild Cognitive Impairment (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27084en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27084
dc.identifier.urihttp://hdl.handle.net/11023/2421
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectMedicine and Surgery
dc.subject.classificationMild Cognitive Impairmenten_US
dc.subject.classificationAlzheimer's Diseaseen_US
dc.subject.classificationDementiaen_US
dc.subject.classificationSubjective Cognitive Concernsen_US
dc.subject.classificationCerebrovascular Diseaseen_US
dc.subject.classificationNeuroimagingen_US
dc.titleNeuroimaging Biomarkers of Alzheimer’s Disease and Cerebrovascular Disease in Patients with Subjective Cognitive Concerns and Mild Cognitive Impairment
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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