Rhinovirus-Bacteria Co-Exposure Modulates CCL20 Induction From Human Bronchial Epithelial Cells

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atmire.migration.oldid4598
dc.contributor.advisorProud, David
dc.contributor.authorMaciejewski, Barbara
dc.contributor.committeememberArmstrong, Glen
dc.contributor.committeememberGiembycz, Mark
dc.contributor.committeememberHirota, Simon
dc.date.accessioned2016-07-08T21:10:16Z
dc.date.available2016-07-08T21:10:16Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractExacerbations of chronic obstructive pulmonary disease (COPD) are often triggered by infection by viral or bacterial pathogens, with human rhinovirus (HRV) and nontypeable Haemophilus influenzae (NTHI) among the most commonly detected pathogens. Patients who suffer from concurrent viral and bacterial infection have more severe exacerbations. CCL20 is a chemokine that attracts immature dendritic cells to the airways, acts as an antimicrobial, and so contributes to both innate and adaptive immune responses to infection. In this thesis, we determined what effect co-infection of human bronchial epithelial (HBE) cells with HRV and bacteria would have on CCL20 induction. HRV/bacterial co-infection resulted in synergistic CCL20 induction in response more than one HRV or bacterial strain. Synergistic CCL20 induction was transcriptionally regulated, and induction was inhibited by cigarette smoke extract (CSE). Impaired induction of CCL20 by CSE raises the prospect of weakened antimicrobial immunity during infections in smokers and patients with COPD.en_US
dc.identifier.citationMaciejewski, B. (2016). Rhinovirus-Bacteria Co-Exposure Modulates CCL20 Induction From Human Bronchial Epithelial Cells (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27664en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27664
dc.identifier.urihttp://hdl.handle.net/11023/3116
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectMicrobiology
dc.subjectImmunology
dc.titleRhinovirus-Bacteria Co-Exposure Modulates CCL20 Induction From Human Bronchial Epithelial Cells
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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