Tetraloop-Receptor Interactions in RNA Crystal Structures
| atmire.migration.oldid | 1166 | |
| dc.contributor.advisor | Zimmerly, Steven | |
| dc.contributor.author | Wu, Li | |
| dc.date.accessioned | 2013-07-15T20:45:00Z | |
| dc.date.available | 2013-11-12T08:00:16Z | |
| dc.date.issued | 2013-07-15 | |
| dc.date.submitted | 2013 | en |
| dc.description.abstract | This dissertation addresses two aspects of RNA tertiary structure. The first section is a computational analysis of tetraloop-receptor interactions in RNA crystal structures. A total of 78 loop-receptor interactions were collected from the Protein Data Bank and grouped into four structural classes. The majority have the standard conformation discovered by earlier studies, indicating that these are the most favoured conformations. However, much structural diversity was found in the rest of this set, and several potential motifs were identified that can be studied in the future. In the second section, a FRET-based analysis was designed to obtain distance information between two selected sites in a group II intron. This project is at an initial stage, and will be extended in future. Together, the results advance our understanding of a specific type of RNA structural motif, and lay groundwork for further modelling a group II intron RNA in the future. | en_US |
| dc.identifier.citation | Wu, L. (2013). Tetraloop-Receptor Interactions in RNA Crystal Structures (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28002 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/28002 | |
| dc.identifier.uri | http://hdl.handle.net/11023/819 | |
| dc.language.iso | eng | |
| dc.publisher.faculty | Graduate Studies | |
| dc.publisher.institution | University of Calgary | en |
| dc.publisher.place | Calgary | en |
| dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | |
| dc.subject | Bioinformatics | |
| dc.subject | Biology--Molecular | |
| dc.subject.classification | RNA crystal structure | en_US |
| dc.subject.classification | tetraloop-receptor interaction | en_US |
| dc.title | Tetraloop-Receptor Interactions in RNA Crystal Structures | |
| dc.type | master thesis | |
| thesis.degree.discipline | Biological Sciences | |
| thesis.degree.grantor | University of Calgary | |
| thesis.degree.name | Master of Science (MSc) | |
| ucalgary.item.requestcopy | true |