An Experimental Approach to Explore Abdominal Aortic Aneurysms in Rabbit Model

Simple item page
atmire.migration.oldid5349
dc.contributor.advisorDi Martino, Elena
dc.contributor.advisorMitha, Alim
dc.contributor.authorAltamimi, Manal Nasser
dc.contributor.committeememberShrive, Nigel
dc.contributor.committeememberAppoo, Jehangir
dc.date.accessioned2017-01-30T22:27:57Z
dc.date.available2017-01-30T22:27:57Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractThe diagnosis of an Abdominal Aortic Aneurysm (AAA) is currently made based on maximum diameter, which fails to accurately predict risks of rupture. The purpose of this study was to advance our understanding of AAA evolution using a rabbit model. AAAs were developed in rabbits using a periaortic incubation of CaCl2 and elastase. Rabbits were imaged using 3D angiography at 0 (healthy), 2, 4, and 6 weeks. Material properties and histological analyses were obtained for each stage. Results showed an increase in maximum diameter and wall thickness with aneurysmal tissue. The healthy aorta was stronger than all aneurysmal tissue. Tissue at 6 weeks had the stiffest and strongest properties compared to aneurysmal tissue. Elastin degradation and separation between wall layers was observed in all aneurysmal tissue with the highest collagen remodeling at 6 weeks. Because human aneurysms are diagnosed at an unknown time after initial formation, control animal experiments are necessary to understand the evolution of the mechanical and histological properties of the aortic tissue.en_US
dc.identifier.citationAltamimi, M. N. (2017). An Experimental Approach to Explore Abdominal Aortic Aneurysms in Rabbit Model (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24886en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/24886
dc.identifier.urihttp://hdl.handle.net/11023/3600
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEngineering--Biomedical
dc.subject.otherAAA
dc.titleAn Experimental Approach to Explore Abdominal Aortic Aneurysms in Rabbit Model
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Collections
Open Theses and Dissertations