Differences in Bone and Cartilage Between Women with Anterior Cruciate Ligament Tears and Healthy Controls

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atmire.migration.oldid5772
dc.contributor.advisorBoyd, Steven
dc.contributor.authorBhatla, Jennifer
dc.contributor.committeememberDunn, Jeffrey
dc.contributor.committeememberShrive, Nigel
dc.date.accessioned2017-07-12T18:24:42Z
dc.date.available2017-07-12T18:24:42Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractAnterior cruciate ligament (ACL) tears increase the risk of osteoarthritis (OA) leading to degradation of cartilage and bone. While the contribution of bone in OA development is unclear, evidence suggests that bone changes accompany cartilage degradation. This study aims to explore the relationship between subchondral compact bone thickness and cartilage thickness by comparing women with ACL reconstructions (ACLR) 5 years post-injury to uninjured controls using magnetic resonance imaging (MRI) and high resolution peripheral quantitative computed tomography (HR-pQCT). We found that ACLR knees had thicker subchondral compact bone in the lateral femur than contralateral knees (12.9% thicker, p=0.013) and injured participants had more subchondral compact bone thickness side-to-side variation than controls (>6.4 times increase, p<0.004). We did not detect cartilage thickness differences (p>0.06). This study demonstrates that subchondral compact bone thickness differences are prominent following injury, as measured by HR-pQCT, which may provide novel insight into OA pathogenesis.en_US
dc.identifier.citationBhatla, J. (2017). Differences in Bone and Cartilage Between Women with Anterior Cruciate Ligament Tears and Healthy Controls (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25708en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25708
dc.identifier.urihttp://hdl.handle.net/11023/3946
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEngineering--Biomedical
dc.subject.otherHR-pQCT
dc.subject.otherMRI
dc.subject.otherCartilage
dc.subject.otherOsteoarthritis
dc.subject.otherBone
dc.subject.otherACL
dc.titleDifferences in Bone and Cartilage Between Women with Anterior Cruciate Ligament Tears and Healthy Controls
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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