Passive Cardiac Properties and Titin Expression in Dilated Cardiomyopathy
| atmire.migration.oldid | 419 | |
| dc.contributor.advisor | Herzog, Walter | |
| dc.contributor.author | McKenzie, Audree | |
| dc.date.accessioned | 2012-10-03T17:33:34Z | |
| dc.date.available | 2012-11-13T08:01:47Z | |
| dc.date.issued | 2012-10-03 | |
| dc.date.submitted | 2012 | en |
| dc.description.abstract | Dilated cardiomyopathy (DCM) is a frequently occurring heart disease characterized by dilation of the left or both ventricles, and systolic and diastolic dysfunctions leading to heart failure. Considering that changes in the expression of titin have been reported to modulate the passive mechanical properties of myocardium and have been associated with human cases of DCM, this study was aimed at relating the passive mechanical properties of myofibrils to the expression of titin in the left ventricle of the Bio TO-2 hamster, a genetic animal model of human DCM, during the progression of the disease. The results of this thesis suggest that a minor change in the expression of titin toward the stiffer N2B isoform occurs with disease progression in the left ventricle of the DCM hamster, but the change is too small to result in a measurable difference between the passive mechanical properties of the DCM and control myofibrils. | en_US |
| dc.identifier.citation | McKenzie, A. (2012). Passive Cardiac Properties and Titin Expression in Dilated Cardiomyopathy (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27266 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/27266 | |
| dc.identifier.uri | http://hdl.handle.net/11023/265 | |
| dc.language.iso | eng | |
| dc.publisher.faculty | Graduate Studies | |
| dc.publisher.institution | University of Calgary | en |
| dc.publisher.place | Calgary | en |
| dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | |
| dc.subject | Engineering--Biomedical | |
| dc.subject.classification | Titin | en_US |
| dc.subject.classification | dilated cardiomyopathy | en_US |
| dc.subject.classification | myofibrils | en_US |
| dc.subject.classification | Bio TO-2 hamster | en_US |
| dc.subject.classification | passive stress | en_US |
| dc.title | Passive Cardiac Properties and Titin Expression in Dilated Cardiomyopathy | |
| dc.type | master thesis | |
| thesis.degree.discipline | Biomedical Engineering | |
| thesis.degree.grantor | University of Calgary | |
| thesis.degree.name | Master of Science (MSc) | |
| ucalgary.item.requestcopy | true |