Cumming School of Medicine

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https://prism.ucalgary.ca/handle/1880/100023

The University of Calgary Faculty of Medicine was established in 1967 and renamed the Cumming School of Medicine in 2014. The Cumming School of Medicine is a national research leader in brain and mental health, chronic diseases and cardiovascular sciences.

Cumming School of Medicine

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    2021 (34th Annual) Sebastian K. Littmann Research Day Abstracts
    (2021-03-05) University of Calgary
    Abstract booklet and program from the Department of Psychiatry's Annual Research Day held March 5, 2021.
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    2022 (35th Annual) Sebastian K. Littmann Research Day Abstracts
    (University of Calgary, 2022-03-04) Patten, Scott
    Abstracts from the 35th annual Sebatian K. Littmann Research Day.
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    2023 Mathison-Littmann Research Day Abstracts
    (2023-03-03) Patten, Scott Burton
    Abstracts from the 2023 Sebastian K. Littmann Research Day at the University of Calgary.
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    350 Needs in Low Resource Settings
    (Presented at Med-e-tel 2005 Conference in Luxembourg, 2005-04-07) Zolfo, M.; Lynen, L.; Huyst, V.; Arnould, L.
    eHealth and Education: Telemedicine is a way to deliver health care in remote areas. Meeting the goal of accessing health information in developing countries and facing the necessity to scale up the use of antiretrovirals (ARVs) in low resource settings, the Institute of Tropical Medicine, Antwerp (ITMA) set up a computer aided training programme for health providers, working in disadvantaged areas. Expert advice from HIV/AIDS specialists about ARVs and management of Opportunistic Infections (OIs) has been offered to colleagues working in different resource limited settings.
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    4th Research and Development Framework Programme (1994-1998). Health Telematics Projects: Final Report.
    (European Comission Directorate General Information Society, 2001-11) Rubis Project (Editor); Kemi-Tornio Polytechnic (Editor); Oulu Polytechnic (Editor); Oulu University (Editor)
    Overview of Health Telematics projects funded by the Healthcare sector of the Telematics Applications Programme (TAP).
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    6-STEPPs: A Modular Tool to Facilitate Clinician Participation in Fair Decisions for Funding New Cancer Drugs
    (2008) Sinclair, Shane; Browman, George P.; Manns, Braden; Hagen, Neil; Chambers, Carole R.; Simon, Anita
    To design a tool to assist clinician participation with cancer drug funding decisions. Public policy-makers and insurers are struggling with funding decisions regarding increasingly expensive new cancer drugs. Increasingly, oncologists are contributing to the process of review that leads to such decisions. We were asked to design a system for ranking new cancer drugs for priority-based funding decisions.
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    An 8-year-old child with delayed diagnosis of Netherton syndrome
    (Hindawi, 2018-01-30) Leung, AK; Barankin, B; Leong, KF
    We report an 8-year-old boy with Netherton syndrome who was misdiagnosed and treated as severe atopic dermatitis. The diagnosis of Netherton syndrome was not made until the child was 8 years of age. We discuss the pitfalls in the diagnosis and alert physicians to the proper and early diagnosis of this syndrome. The child was treated with a low dose (0.25 mg/kg) of oral acitretin and a topical moisturizer with marked improvement of his skin and pruritus in 2 months. At 6-month follow-up, the skin was almost clear of erythema and scaling, and the hair was longer and stronger. The dose of acitretin was reduced to 0.12 mg/kg for another 6 months and then discontinued.
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    A Functional Magnetic Resonance Imaging Study to Investigate the Utility of a Picture Imagination Task in Investigating Neural Responses in Patients with Chronic Musculoskeletal Pain to Daily Physical Activity Photographs
    (Public Library of Science (PLoS), 2015-10-23) Taylor, Ann M.; Harris, Ashley D.; Varnava, Alice; Phillips, Rhiannon; Taylor, Justin O.; Hughes, Owen; Wilkes, Antony R.; Hall, Judith E.; Wise, Richard G.
    Pain-related anxiety and fear are associated with increased difficulties in attention, increased awareness of pain, impaired disengagement from pain, and can moderate the effects of attentional coping attempts. Accurately assessing the direct impact of pain-related anxiety and fear on pain behavior has proved difficult. Studies have demonstrated no or limited influence of pain-related fear and anxiety on behavior but this may be due to inherent problems with the scales used. Neuroimaging has improved the understanding of neural processes underlying the factors that influence pain perception. This study aimed to establish if a Picture and Imagination Task (PIT), largely developed from the Photographs of Daily Activity (PHODA) assessment tool, could help explore how people living with chronic pain process information about daily activities. Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) was used to compare brain responses in patients with chronic musculoskeletal pain (CMSKP) (n = 15) and healthy controls (n = 15). Subjects were asked to imagine how they would feel mentally and physically if asked to perform daily activities illustrated in PIT. The results found that a number of regions involved in pain processing saw increased BOLD activation in patients compared with controls when undertaking the task and included the insula, anterior cingulate cortex, thalamus and inferior and superior parietal cortices. Similarly, increased BOLD responses in patients compared to controls in the frontal pole, paracingulate and the supplementary motor cortex may be suggestive of a memory component to the responses The amygdala, orbitofrontal cortex, substantia nigra/ventral tegmentum, putamen, thalamus, pallidum, inferior parietal (supramarginal and angular gyrus) and cingulate cortex were also seen to have greater differences in BOLD signal changes in patients compared with controls and many of these regions are also associated with general phobic responses. Therefore, we suggest that PIT is a useful task to explore pain-and movement-related anxiety and fear in fMRI studies. Regions in the Default Mode Network remained active or were less deactivated during the PIT task in patients with CMSKP compared to healthy controls supporting the contention that the DMN is abnormal in patients with CMSKP.
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    A Longitudinal Seroepidemiology Study to Evaluate Antibody Response to SARS-CoV-2 Virus and Vaccination in Children in Calgary, Canada from July 2020 to September 2022.
    (Canadian Immunization Conference, 2023-04-19) Doucette, Emily Jayne; Kellner, James Duncan
    Introduction: Measurement of SARS-CoV-2 antibody seropositivity is important to accurately understand exposure to infection and/or vaccination in populations. Methods: A cohort of children with or without prior SARS-CoV-2 infections was enrolled in Calgary, Canada in 2020. Venous blood was sampled 4 times from July 2020 to April 2022 for SARS-CoV-2 nucleocapsid and spike antibodies, with an additional 5th visit in the fall of 2022. Demographic and clinical information was obtained including SARS-CoV-2 test results and vaccination records. Results and analysis: 1035 children were enrolled and 88.9% completed 4 visits; median age 9 years (IQR: 5,13); 519 (50.1%) female; and 815 (78.7%) Caucasian. 477 (46.1%) participants attended Visit 5. Before enrollment, 118 (11.4%) had confirmed or probable SARS-CoV-2 infection. By September 2022, the total cumulative percentage of previously uninfected participants diagnosed with COVID-19 was 53.9% by Visit 5. (0/917 (0%), 15/873 (1.7%), 31/837 (3.7%), 280/820 (34.1%), and 63/439 (14.4%) at Visits 1-5, respectively). Nucleocapsid antibody seropositivity declined to 18.0% after more than 200 days after diagnosis. In contrast, spike antibodies remained elevated in 97.6% of unvaccinated children after more than 400 days after diagnosis. By September 2022, 97.1% (232/239) of children 12 years and older, 85.9% (171/199) of children 5-11, and 15.4% (6/39) of children under 5 received at least 1 dose of vaccine. At that time, all 409 vaccinated children had spike antibodies, compared with 38/64 (59.4%) of unvaccinated children (P<0.001 for comparison of proportions). Conclusions: By September 2022, most children in the study had a serologic response against the SARS-CoV-2 virus from infection and/or vaccination, with unvaccinated children much less likely to have a serologic response. Ongoing studies of serologic status are needed to estimate population levels of virus exposure and durability of antibody response after infection and/or vaccination.
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    Absence of clinical relationship between oxidized low density lipoproteins and diabetic peripheral neuropathy: a case control study
    (BioMed Central, 2014-02-12) Rosales-Hernandez, Alma; Cheung, Audrey; Podgorny, Peter; Chan, Cynthia; Toth, Cory
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    Absent right and persistent left superior vena cava: troubleshooting during a challenging pacemaker implant: a case report
    (BioMed Central, 2014-07-21) Jacques Rizkallah; John Burgess; Kuriachan, Vikas P.
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    Abstracts from the 2018 Sebastian K. Littmann Research Day
    (2018-03-02) Patten, Scott B.
    These are the abstracts from the 2018 research day, held on March 2nd 2018.
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    Abstracts from the 2020 Sebastian K. Littmann Research Day
    (2020-03-06) Patten, Scott B.
    These are the abstracts from the 33rd Annual Sebastian K. Littmann Research Day, held on March 6, 2020.
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    Access and Authorisation in a Glocal e-Health Policy Context: Session II: Access Control to Information and Authorisation Management.
    (Health Telematics Unit, University of Calgary, 2003-05-31) Scott, Richard E.; Jennett, Penny A.; Yeo, Maryann
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    Accuracy of portrayal by standardized patients: Results from four OSCE stations conducted for high stakes examinations
    (BioMed Central, 2014-5-6) Baig, Lubna A.; Beran, Tanya N.; Vallevand, Andrea; Baig, Zarrukh A.; Monroy-Cuadros, Mauricio
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    The accuracy of pulse oximetry in emergency department patients with severe sepsis and septic shock: a retrospective cohort study
    (BioMed Central, 2010-05-05) Wilson, Ben J.; Cowan, Hamish J.; Lord, Jason A.; Zuege, Dan J.; Zygun, David A.
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    Acellular pertussis vaccine effectiveness and waning immunity in Alberta, Canada: 2010–2015, a Canadian Immunization Research Network (CIRN) study
    (2019-06-01) Bell, Christopher A.; Russell, Margaret L.; Drews, Steven J.; Simmonds, Kimberley A.; Svenson, Lawrence W.; Schwartz, Kevin L.; Kwong, Jeffrey C.; Mahmud, Salaheddin M.; Crowcroft, Natasha S.
    Background Pertussis is still frequently reported in Canada. In Alberta, pertussis incidence ranged from 1.8 to 20.5 cases per 100,000 persons for 2004–2015. Most cases occurred in those aged <15 years. In Alberta, acellular formulations replaced whole-cell in 1997. We investigated pertussis vaccine effectiveness (VE) using a test-negative design (TND) study. Methods We included all persons who had a real-time PCR laboratory test for Bordetella pertussis between January 1, 2010 and August 31, 2015, in the province of Alberta, Canada. Vaccination history was obtained from Alberta’s immunization repository. Vaccination status was classified as complete, incomplete, or unvaccinated, based on the province’s vaccination schedule. Persons who had received ≥one dose of whole cell vaccine were excluded from analysis. Multivariable logistic regression models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) for pertussis infection by time since last vaccination. We adjusted for vaccination status, age, sex, neighbourhood income, urban/rural status, and the presence of a co-morbid condition. VE was calculated as [(1 − aOR) * 100]. Results Of the 12,149 tests available, 936 (7.7%) were positive for Bordetella pertussis. Among the full cohort, VE was 90% (95% CI 87–92%) at 1 year, 81% (95% CI 77–85%) at 1–3 years, 76% (95% CI 68–82%) at 4–7 years, and 37% (95% CI 11–56%) at 8 or more years since a last dose of acellular pertussis vaccine. Conclusions Pertussis VE was highest in the first year after vaccination, then declined noticeably as years since a last vaccination increased. Our results suggest that a large number of adolescents and adults are susceptible to infection with Bordetella pertussis. Regular boosters throughout childhood, adolescence, and during pregnancy may be needed.