An Analysis of a Cohort of Surgical-Related Intra-Abdominal Sepsis with PIRO
Date
2013-07-10
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Abstract
Introduction: Sepsis constitutes an important cause of morbidity and mortality; mortality in patients with intraabdominal sepsis remains high. The PIRO concept is a classification scheme for sepsis. Methods: Retrospective analysis of a prospective observational cohort. Results: 905 patients were analyzed. A PIRO score was developed including the following variables: age > 65 years, comorbidities, leukopenia, hypothermia, cardiovascular, renal, respiratory, and CNS failure, one point was given for each present feature. The mean PIRO score was significantly higher in nonsurvivors than in survivors (3.9 vs. 2.3 respectively, p < 0.0001). When the patients were distributed according PIRO scoring, mortality rate increased (p <0.0001). The aROC showed consistent mortality discrimination by PIRO score (0.80, 95%CI 0.79 to 0.83), outperforming APACHE II (0.72, 95%CI 0.68 to 0.75) and SOFA (0.72, 95%CI 0.68 to 0.76) p <0.0001. Conclusion: The PIRO score performed well as an ICU mortality predictor tool for surgical related intra-abdominal sepsis.m
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Medicine and Surgery
Citation
Posadas Calleja, J. G. (2013). An Analysis of a Cohort of Surgical-Related Intra-Abdominal Sepsis with PIRO (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24829