Resting State Functional Connectivity in People at Clinical High Risk for Psychosis
Date
2013-07-15
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Abstract
Neuroimaging studies in participants at clinical high risk (CHR) for psychosis may provide evidence into the etiology of psychosis. Abnormalities in connectivity have been reported in schizophrenia but little is known about resting state functional connectivity (RSFC) prior to the onset of psychosis. The aim of this project was to identify functional neuroimaging markers for individuals at CHR. It was hypothesized that each network investigated, including the default mode, salience, executive control and dorsal attention network, would show aberrant connectivity in the CHR sample.
Thirty-one CHR participants who met Criteria of Prodromal Syndromes and 12 healthy controls (HC) were scanned using resting-state fMRI. Seed‐based region-of‐interest correlation analysis was used to identify the default mode, salience, executive control, and dorsal attention networks.
Compared to HC, people at CHR demonstrated aberrancies in all four resting state networks that were tested. Results indicated resting state networks have altered patterns of connectivity in people at CHR for psychosis, when compared to HC. Each network tested was differentially affected. Aberrancies in RSFC suggest that functional specialization is altered in individuals at CHR who, in turn, may have difficulty properly allocating attentional resources between internal and external stimuli, even prior to the onset of psychosis.
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Keywords
Neuroscience, Mental Health, Psychology--Clinical
Citation
Abraham, N. (2013). Resting State Functional Connectivity in People at Clinical High Risk for Psychosis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27654