Use 'em and lose 'em-activity-induced removal of calcium channels from the plasma membrane
Date
2007-08-16
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Elsevier Inc.
Abstract
Calcium influx via L-type (Cav1.2 and Cav1.3) calcium channels is tightly regulated to ensure optimal intracellular calcium levels. Although much is known about acute modulation of these channels by second messengers, the mechanisms that control their trafficking to and from the plasma membrane remain poorly understood. In this issue of Neuron, Green and colleagues demonstrate that the opening of L-type calcium channels results in negative feedback regulation due to their calcium-dependent internalization.
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Citation
Varela, D., & Zamponi, G. W. (2007, August 16). Use ’em and Lose ’em-Activity-Induced Removal of Calcium Channels from the Plasma Membrane. Neuron. https://doi.org/10.1016/j.neuron.2007.07.033