• Information Technology
  • Human Resources
  • Careers
  • Giving
  • Library
  • Bookstore
  • Active Living
  • Continuing Education
  • Go Dinos
  • UCalgary Maps
  • UCalgary Directory
  • Academic Calendar
My UCalgary
Webmail
D2L
ARCHIBUS
IRISS
  • Faculty of Arts
  • Cumming School of Medicine
  • Faculty of Environmental Design
  • Faculty of Graduate Studies
  • Haskayne School of Business
  • Faculty of Kinesiology
  • Faculty of Law
  • Faculty of Nursing
  • Faculty of Nursing (Qatar)
  • Schulich School of Engineering
  • Faculty of Science
  • Faculty of Social Work
  • Faculty of Veterinary Medicine
  • Werklund School of Education
  • Information TechnologiesIT
  • Human ResourcesHR
  • Careers
  • Giving
  • Library
  • Bookstore
  • Active Living
  • Continuing Education
  • Go Dinos
  • UCalgary Maps
  • UCalgary Directory
  • Academic Calendar
  • Libraries and Cultural Resources
View Item 
  •   PRISM Home
  • Arts
  • Arts Research & Publications
  • View Item
  •   PRISM Home
  • Arts
  • Arts Research & Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Serotonergic enhancement of circadian responses to light: Role of the raphe and intergeniculate leaflet

Thumbnail
Download
Post-print/accepted manuscript (746.1Kb)
Download Record
Download to EndNote/RefMan (RIS)
Download to BibTex
Author
Smith, Victoria M
Jeffers, Ryan T
Antle, Michael C
Accessioned
2016-05-18T22:21:02Z
Available
2016-05-18T22:21:02Z
Issued
2015-11
Type
journal article
Metadata
Show full item record

Abstract
Light serves as the primary stimulus that synchronizes the circadian clock in the suprachiasmatic nucleus (SCN) to the external day-night cycle. Appropriately timed light exposure can reset the phase of the circadian clock. Some serotonergic drugs that bind to the 5-HT1A receptor can enhance phase shifts to light. The mechanism by which this potentiation occurs is not well understood. In this study we examine where in the hamster brain one of these drugs, BMY7378, might be working. Systemic (5 mg/kg), intradorsal raphe and intra-median raphe (both 15.6 nmol in 0.5 μl), but not intra-SCN (7.8 nmol or 15.6 nmol in 0.5 μl) injections of BMY7378 significantly potentiated phase shifts to light. Potentiation of photic shifts persisted when serotonergic innervation of the SCN was lesioned with infusions of the serotonin neurotoxin 5,7-dihydroxytryptamine into the SCN. Light-induced c-Fos expression in the rostral and caudal intergeniculate leaflet (IGL) was attenuated with systemic BMY7378, suggesting that the IGL may be involved in this response. Both complete IGL lesions and depletion of serotonergic innervation of the IGL prevented systemic BMY7378 from potentiating photic phase shifts. Together these findings suggest that the mechanism by which BMY7378 enhances photic responses is by changing the activity of the raphe nuclei to influence how the IGL responds to light, which subsequently influences the SCN as one of its downstream targets. Identification of the network that underlies this potentiation could lead to the development of useful therapeutic interventions for treating sleep and circadian disorders
Grantingagency
NSERC
Refereed
Yes
Department
Psychology
Faculty
Arts
Institution
University of Calgary
Publisher
Wiley
Doi
http://dx.doi.org/10.1111/ejn.13064
http://dx.doi.org/10.11575/PRISM/33346
Uri
http://hdl.handle.net/1880/51235
Collections
  • Arts Research & Publications

Browse

All of PRISMCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Download Results

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

  • Email
  • SMS
  • 403.220.8895
  • Live Chat

Energize: The Campaign for Eyes High

Privacy Policy
Website feedback

University of Calgary
2500 University Drive NW
Calgary, AB T2N 1N4
CANADA

Copyright © 2017