Tibial-fibular geometry and density variations associated with elevated bone strain and sex disparities in young active adults

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dc.contributor.authorBruce, Olivia L
dc.contributor.authorBaggaley, Michael
dc.contributor.authorKhassetarash, Arash
dc.contributor.authorHaider, Ifaz T
dc.contributor.authorEdwards, W Brent
dc.date.accessioned2022-11-03T20:36:28Z
dc.date.available2022-11-03T20:36:28Z
dc.date.issued2022-05-20
dc.description.abstractTibial stress fracture is a common injury in runners and military personnel. Elevated bone strain is believed to be associated with the development of stress fractures and is influenced by bone geometry and density. The purpose of this study was to characterize tibial-fibular geometry and density variations in young active adults, and to quantify the influence of these variations on finite element-predicted bone strain. A statistical appearance model characterising tibial-fibular geometry and density was developed from computed tomography scans of 48 young physically active adults. The model was perturbed ±1 and 2 standard deviations along each of the first five principal components to create finite element models. Average male and female finite element models, controlled for scale, were also generated. Muscle and joint forces in running, calculated using inverse dynamics-based static optimization, were applied to the finite element models. The resulting 95th percentile pressure-modified von Mises strain (peak strain) and strained volume (volume of elements above 4000 με) were quantified. Geometry and density variations described by principal components resulted in up to 12.0% differences in peak strain and 95.4% differences in strained volume when compared to the average tibia-fibula model. The average female illustrated 5.5% and 41.3% larger peak strain and strained volume, respectively, when compared to the average male, suggesting that sexual dimorphism in bone geometry may indeed contribute to greater stress fracture risk in females. Our findings identified important features in subject-specific geometry and density associated with elevated bone strain that may have implications for stress fracture risk.en_US
dc.description.grantingagencyNatural Sciences and Engineering Research Council (NSERC)en_US
dc.identifier.citationBruce, O. L., Baggaley, M., Khassetarash, A., Haider, I. T., & Edwards, W. B. (2022). Tibial-fibular geometry and density variations associated with elevated bone strain and sex disparities in young active adults. Bone, 161, 116443. https://doi.org/10.1016/j.bone.2022.116443en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.bone.2022.116443en_US
dc.identifier.grantnumberRGPIN 01029-2015, 02404-2021, CGS D – 534891 - 2019, NSERC CREATE Wearable Technology Research and Collaboration training programen_US
dc.identifier.issn8756-3282
dc.identifier.urihttp://hdl.handle.net/1880/115408
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.publisher.departmentOtheren_US
dc.publisher.facultyKinesiologyen_US
dc.publisher.facultySchulich School of Engineeringen_US
dc.publisher.hasversionacceptedVersionen_US
dc.publisher.policyhttps://www.elsevier.com/about/policies/sharingen_US
dc.rightsUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.subjectfinite element analysisen_US
dc.subjectlower extremityen_US
dc.subjectmorphologyen_US
dc.subjectstress fractureen_US
dc.subjectStatistical appearance modelen_US
dc.titleTibial-fibular geometry and density variations associated with elevated bone strain and sex disparities in young active adultsen_US
dc.typejournal articleen_US
ucalgary.item.requestcopytrueen_US
ucalgary.scholar.levelGraduateen_US
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