Advances in the Management of Meconium Aspiration Syndrome

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dc.contributor.authorSwarnam, Kamala
dc.contributor.authorSoraisham, Amuchou S.
dc.contributor.authorSivanandan, Sindhu
dc.date.accessioned2018-09-27T11:54:19Z
dc.date.available2018-09-27T11:54:19Z
dc.date.issued2011-11-22
dc.date.updated2018-09-27T11:54:19Z
dc.description.abstractMeconium aspiration syndrome (MAS) is a common cause of severe respiratory distress in term infants, with an associated highly variable morbidity and mortality. MAS results from aspiration of meconium during intrauterine gasping or during the first few breaths. The pathophysiology of MAS is multifactorial and includes acute airway obstruction, surfactant dysfunction or inactivation, chemical pneumonitis with release of vasoconstrictive and inflammatory mediators, and persistent pulmonary hypertension of newborn (PPHN). This disorder can be life threatening, often complicated by respiratory failure, pulmonary air leaks, and PPHN. Approaches to the prevention of MAS have changed over time with collaboration between obstetricians and pediatricians forming the foundations for care. The use of surfactant and inhaled nitric oxide (iNO) has led to the decreased mortality and the need for extracorporeal membrane oxygenation (ECMO) use. In this paper, we review the current understanding of the pathophysiology and management of MAS.
dc.description.versionPeer Reviewed
dc.identifier.citationKamala Swarnam, Amuchou S. Soraisham, and Sindhu Sivanandan, “Advances in the Management of Meconium Aspiration Syndrome,” International Journal of Pediatrics, vol. 2012, Article ID 359571, 7 pages, 2012. doi:10.1155/2012/359571
dc.identifier.doihttps://doi.org/10.1155/2012/359571
dc.identifier.urihttp://hdl.handle.net/1880/108379
dc.identifier.urihttps://doi.org/10.11575/PRISM/43996
dc.language.rfc3066en
dc.rights.holderCopyright © 2012 Kamala Swarnam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleAdvances in the Management of Meconium Aspiration Syndrome
dc.typeJournal Article
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