The Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit knee
Date
2014-08-07
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Abstract
Excessive joint loading has been associated with the onset and an increased rate of progression of
osteoarthritis, but little is known about the effects of exercise loading on synovial fluid (SF)
composition and chondrocytes viability. The purpose of this study was to load intact knee joints
with two types of controlled maximal muscular contractions (low, and high intensity exercise) and
identify changes in synovial fluid protein composition and chondrocyte death. We found that:
1. Chondrocytes are well protected to withstand very high loads over a short period of time,
and maximal endurance loading.
2. High intensity, short duration exercise did not change total protein concentration in SF.
However, it decreased the number of identifiable proteins.
3. Low intensity, long duration exercise did not change total protein concentration in the SF,
but it increased the number of identifiable proteins.
Description
Keywords
Engineering--Biomedical
Citation
Abughazaleh, N. (2014). The Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit knee (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28212