The Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit knee

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atmire.migration.oldid2386
dc.contributor.advisorHerzog, Walter
dc.contributor.authorAbughazaleh, Nada
dc.date.accessioned2014-08-07T20:39:30Z
dc.date.available2014-11-17T08:00:40Z
dc.date.issued2014-08-07
dc.date.submitted2014en
dc.description.abstractExcessive joint loading has been associated with the onset and an increased rate of progression of osteoarthritis, but little is known about the effects of exercise loading on synovial fluid (SF) composition and chondrocytes viability. The purpose of this study was to load intact knee joints with two types of controlled maximal muscular contractions (low, and high intensity exercise) and identify changes in synovial fluid protein composition and chondrocyte death. We found that: 1. Chondrocytes are well protected to withstand very high loads over a short period of time, and maximal endurance loading. 2. High intensity, short duration exercise did not change total protein concentration in SF. However, it decreased the number of identifiable proteins. 3. Low intensity, long duration exercise did not change total protein concentration in the SF, but it increased the number of identifiable proteins.en_US
dc.identifier.citationAbughazaleh, N. (2014). The Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit knee (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28212en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28212
dc.identifier.urihttp://hdl.handle.net/11023/1673
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEngineering--Biomedical
dc.subject.classificationchondrocytes viabilityen_US
dc.subject.classificationsynovial fluid (SF)en_US
dc.subject.classificationmuscular contractionsen_US
dc.subject.classificationprotein concentrationen_US
dc.subject.classificationEccentric Exerciseen_US
dc.subject.classificationConcentric Exerciseen_US
dc.titleThe Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit knee
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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