The protocol for the Cannabidiol in children with refractory epileptic encephalopathy (CARE-E) study: a phase 1 dosage escalation study

Simple item page
dc.contributor.authorReithmeier, Darren
dc.contributor.authorTang-Wai, Richard
dc.contributor.authorSeifert, Blair
dc.contributor.authorLyon, Andrew W
dc.contributor.authorAlcorn, Jane
dc.contributor.authorActon, Bryan
dc.contributor.authorCorley, Scott
dc.contributor.authorProsser-Loose, Erin
dc.contributor.authorMousseau, Darrell D
dc.contributor.authorLim, Hyun J
dc.contributor.authorTellez-Zenteno, Jose
dc.contributor.authorHuh, Linda
dc.contributor.authorLeung, Edward
dc.contributor.authorCarmant, Lionel
dc.contributor.authorHuntsman, Richard J
dc.date.accessioned2018-09-26T12:04:28Z
dc.date.available2018-09-26T12:04:28Z
dc.date.issued2018-07-07
dc.date.updated2018-09-26T12:04:28Z
dc.description.abstractAbstract Background Initial studies suggest pharmaceutical grade cannabidiol (CBD) can reduce the frequency of convulsive seizures and lead to improvements in quality of life in children affected by epileptic encephalopathies. With limited access to pharmaceutical CBD, Cannabis extracts in oil are becoming increasingly available. Physicians show reluctance to recommend Cannabis extracts given the lack of high quality safety data especially regarding the potential for harm caused by other cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC). The primary aims of the study presented in this protocol are (i) To determine whether CBD enriched Cannabis extract is safe and well-tolerated for pediatric patients with refractory epilepsy, (ii) To monitor the effects of CBD-enriched Cannabis extract on the frequency and duration of seizure types and on quality of life. Methods Twenty-eight children with treatment resistant epileptic encephalopathy ranging in age from 1 to 10 years will be recruited in four Canadian cities into an open-label, dose-escalation phase 1 trial. The primary objectives for the study are (i) To determine if the CBD-enriched Cannabis herbal extract is safe and well-tolerated for pediatric patients with treatment resistant epileptic encephalopathy and (ii) To determine the effect of CBD-enriched Cannabis herbal extract on the frequency and duration of seizures. Secondary objectives include (i) To determine if CBD-enriched Cannabis herbal extracts alter steady-state levels of co-administered anticonvulsant medications. (ii) To assess the relation between dose escalation and quality of life measures, (iii) To determine the relation between dose escalation and steady state trough levels of bioactive cannabinoids. (iv) To determine the relation between dose escalation and incidence of adverse effects. Discussion This paper describes the study design of a phase 1 trial of CBD-enriched Cannabis herbal extract in children with treatment-resistant epileptic encephalopathy. This study will provide the first high quality analysis of safety of CBD-enriched Cannabis herbal extract in pediatric patients in relation to dosage and pharmacokinetics of the active cannabinoids. Trial registration http://clinicaltrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2016 Dec 16. Identifier NCT03024827, Cannabidiol in Children with Refractory Epileptic Encephalopathy: CARE-E; 2017 Jan 19 [cited 2017 Oct]; Available from: http://clinicaltrials.gov/ct2/show/NCT03024827
dc.identifier.citationBMC Pediatrics. 2018 Jul 07;18(1):221
dc.identifier.doihttps://doi.org/10.1186/s12887-018-1191-y
dc.identifier.urihttp://hdl.handle.net/1880/107926
dc.identifier.urihttps://doi.org/10.11575/PRISM/44031
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.titleThe protocol for the Cannabidiol in children with refractory epileptic encephalopathy (CARE-E) study: a phase 1 dosage escalation study
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
12887_2018_Article_1191.pdf
Size:
868.62 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Publications