Antihyperalgesic effect of joint mobilization requires Cav3.2 calcium channels
Date
2023-07-18
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Abstract
The present study was undertaken to explore the relative contributions of Cav3.2 T-type channels to mediating the antihyperalgesic activity of joint manipulation (JM) therapy. We used the chronic constriction injury model (CCI) to induce peripheral neuropathy and chronic pain in male mice, followed by JM. We demonstrate that JM produces long-lasting mechanical anti-hyperalgesia that is abolished in Cav3.2 null mice. Moreover, we found that JM displays a similar analgesic profile as the fatty acid amide hydrolase inhibitor URB597, suggesting a possible converging mechanism of action involving endocannabinoids. Overall, our findings advance our understanding of the mechanisms through which JM produces analgesia.
Description
Keywords
Citation
Molecular Brain. 2023 Jul 18;16(1):60