The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels

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dc.contributor.authorSimms, Brent A.
dc.contributor.authorZamponi, Gerald W.
dc.date.accessioned2018-05-29T15:04:35Z
dc.date.available2018-05-29T15:04:35Z
dc.date.issued2012-03-02
dc.description.abstractA loss of function of the L-type calcium channel, Cav1.2, results in a cardiac specific disease known as Brugada syndrome. Although many Brugada syndrome channelopathies reduce channel function, one point mutation in the N-terminus of Cav1.2 (A39V) has been shown to elicit disease a phenotype because of a loss of surface trafficking of the channel. This lack of cell membrane expression could not be rescued by the trafficking chaperone CavĪ².en_US
dc.description.sponsorshipSponsored by the Open Access Authors Funden_US
dc.identifier.citationSimms, B. A., & Zamponi, G. W. (2012). The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels. Molecular Brain, 5(1). https://doi.org/10.1186/1756-6606-5-9en_US
dc.identifier.doihttp://dx.doi.org/10.1186/1756-6606-5-9en_US
dc.identifier.urihttp://hdl.handle.net/1880/106698
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleThe Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channelsen_US
dc.typejournal articleen_US
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