Salivary alpha-amylase during pregnancy: Diurnal course and associations with obstetric history, maternal demographics and mood

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dc.contributor.authorGiesbrecht, Gerald
dc.contributor.authorGranger, Douglas
dc.contributor.authorCampbell, Tavis
dc.contributor.authorKaplan, Bonnie
dc.contributor.authorAPrON Study Team
dc.date.accessioned2015-11-07T04:25:39Z
dc.date.available2015-11-07T04:25:39Z
dc.date.issued2013-03
dc.descriptionAuthor's accepted manuscript deposited according to Wiley archiving policies: http://olabout.wiley.com/WileyCDA/Section/id-820227.htmlen_US
dc.description.abstractDiurnal patterns of salivary alpha amylase (sAA) in pregnant women have not previously been described. The current study employed ecological momentary assessment to examine the association between the diurnal sAA, obstetric history, maternal demographics, and mood during pregnancy. Saliva was self-collected by 83 pregnant women (89% White, age 25.3-43.0 years; mean gestational age 21.9 weeks, range 6-37 weeks; gravida 1-6) at home over three days. Results indicated that current pregnancy (gestational age and fetal sex) and maternal demographics were not related to diurnal sAA. In contrast, a history of previous miscarriage (Parameter = -.17; SE = .05; p < .05) was associated with an atypical diurnal pattern. Even after accounting for obstetric history, trait anxiety (Parameter = .16; SE = .04; p < .001) was associated with increased sAA over the day while chronic levels of fatigue (Parameter = -.06; SE = .03; p < .05) were associated with decreased sAA. In a separate model, we also tested the time varying covariation of sAA and mood. The effects of momentary mood were in contrast to those for trait mood. Both momentary depression (Parameter = .22; SE = .09; p < .01) and vigour/positive mood (Parameter = .12; SE = .04; p < .001) were associated with momentary increases in sAA while momentary anxiety and fatigue were not related to sAA. The findings suggest that basal sAA during pregnancy is sensitive to emotional arousal. Evaluating diurnal patterns of sAA holds promise for advancing understanding of how emotional arousal during pregnancy may affect fetal development.en_US
dc.description.refereedYesen_US
dc.description.sponsorshipThis research was supported in part by funding from Alberta Innovates Health Solutions, the Alberta Children’s Hospital Research Institute, and the Department of Paediatrics, University of Calgary. The authors thank the participants of the Pregnancy Mood and Cortisol study for the time and effort they contributed to this research and Claudia Buss for helpful comments on a previous draft of this paper.en_US
dc.identifier.citationGiesbrecht, G.F., Granger, D., Campbell, T., & Kaplan, B. and the APrON Study Team. (2013). Salivary alpha-amylase during pregnancy: Diurnal course and associations with obstetric history, maternal characteristics and mood. Developmental Psychobiology, 55, 156-167.en_US
dc.identifier.doi10.1002/dev.21008
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33653
dc.identifier.urihttp://hdl.handle.net/1880/51012
dc.language.isoenen_US
dc.publisherDevelopmental Psychobiologyen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentDepartment of Paediatricsen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2302en_US
dc.subjectsalivary alpha-amylaseen_US
dc.subjectpsychological distressen_US
dc.subjectpregnancyen_US
dc.subjectstressen_US
dc.subjectmooden_US
dc.subjectobstetric historyen_US
dc.titleSalivary alpha-amylase during pregnancy: Diurnal course and associations with obstetric history, maternal demographics and mooden_US
dc.typejournal article
thesis.degree.disciplinePaediatrics
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