Invasive Streptococcus pneumoniae Infection Causing Hemolytic Uremic Syndrome in Children: Two Recent Cases

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dc.contributor.authorVanderkooi, Otto G
dc.contributor.authorKellner, James D
dc.contributor.authorWade, Andrew W
dc.contributor.authorJadavji, Tajdin
dc.contributor.authorMidgley, Julian P
dc.contributor.authorLouie, Thomas
dc.contributor.authorTyrrell, Gregory J
dc.date.accessioned2018-09-27T12:22:24Z
dc.date.available2018-09-27T12:22:24Z
dc.date.issued2003-01-01
dc.date.updated2018-09-27T12:22:24Z
dc.description.abstractINTRODUCTION: Streptococcus pneumoniae is an uncommon cause of hemolytic uremic syndrome (HUS) with a unique pathophysiology that differs from Shiga toxin-related HUS.METHODS: Case descriptions for each patient are provided. Each strain of S pneumoniae was subjected to a pulsed-field gel electrophoresis (PFGE) analysis, Shiga toxin assay and polymerase chain reaction to detect Shiga toxin genes. A review of the current literature was conducted.CASE PRESENTATIONS: Two patients with S pneumoniae-related HUS that presented to the Alberta Children's Hospital, Calgary, Alberta, within four weeks of each other in 2001 are described. Both presented with pneumonia and empyema with associated HUS. Both patients required dialysis, one patient for 10 days and the other for 18 days. Neither patient demonstrated evidence of Shiga toxin-related disease. S pneumoniae isolated from blood or pleural fluid was penicillin susceptible. One isolate was serotype 3 and the other was serotype 14. The two strains had different PFGE patterns. Both patients recovered well with no persistent renal dysfunction.CONCLUSIONS: S pneumoniae continues to be an uncommon but important cause of HUS. Most cases can be confirmed or at least considered probable without performing a renal biopsy.
dc.description.versionPeer Reviewed
dc.identifier.citationOtto G Vanderkooi, James D Kellner, Andrew W Wade, et al., “Invasive Streptococcus pneumoniae Infection Causing Hemolytic Uremic Syndrome in Children: Two Recent Cases,” Canadian Journal of Infectious Diseases, vol. 14, no. 6, pp. 339-343, 2003. doi:10.1155/2003/219027
dc.identifier.doihttps://doi.org/10.1155/2003/219027
dc.identifier.urihttp://hdl.handle.net/1880/108587
dc.language.rfc3066en
dc.rights.holderCopyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleInvasive Streptococcus pneumoniae Infection Causing Hemolytic Uremic Syndrome in Children: Two Recent Cases
dc.typeJournal Article
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