Activation of M1/4 receptors phase advances the hamster circadian clock during the day

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dc.contributor.authorBasu, Priyoneel
dc.contributor.authorWensel, Adrienne L
dc.contributor.authorMcKibbon, Reid
dc.contributor.authorLefebvre, Nicole
dc.contributor.authorAntle, Michael C
dc.date.accessioned2016-05-18T21:36:05Z
dc.date.available2016-05-18T21:36:05Z
dc.date.issued2016-05-16
dc.description.abstractThe mammalian circadian clock in the suprachiasmatic nucleus (SCN) can be reset by the cholinergic agonist carbachol. In hamsters, intraSCN carbachol produces phase advances during the day. This phenomenon has previously been attributed to the muscarinic receptors, as carbachol-induced phase shifts are blocked by pretreatment with the muscarinic antagonist atropine. The SCN contains all five muscarinic receptors, leaving open the question as to which muscarinic receptors mediate these shifts. Here we test two selective muscarinic agonists, the M1/4 agonist McN-A-343 and the M2/3 agonist bethanechol, in addition to the non-selective cholinergic agonist carbachol. Consistent with previous reports, carbachol produced significant phase advances when injected to the SCN during the mid-subjective day. At the doses used here, McN-A-343, but not bethanechol, also produced significant phase shifts when injected to the SCN during the mid-subjective day. Phase shifts to McN-A-343 were as large as those produced by carbachol, suggesting that activation of the M1/4 receptors alone can fully account for the daytime phase advances produced by cholinergic agonists. Given acetylcholine’s role in arousal, and the similarity between phase advances to carbachol/McN-A-343 and to exercise and arousal manipulations, it is possible that acetylcholine may contribute to non-photic resetting of the circadian clock.en_US
dc.description.grantingagencyNSERCen_US
dc.description.refereedYesen_US
dc.identifier.doi10.1016/j.neulet.2016.04.012
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33341
dc.identifier.grantnumberRGPIN-2016-04059en_US
dc.identifier.urihttp://hdl.handle.net/1880/51234
dc.publisherElsevieren_US
dc.publisher.departmentPsychologyen_US
dc.publisher.facultyArtsen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.titleActivation of M1/4 receptors phase advances the hamster circadian clock during the dayen_US
dc.typejournal article
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