Pneumococcal Disease Trends in the Post-Vaccine Era in Calgary, Canada: An Interrupted Time Series Analysis

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dc.contributor.authorRicketson, Leah
dc.contributor.authorKellner, James D
dc.contributor.authorCASPER Investigators
dc.date.accessioned2022-06-13T17:11:30Z
dc.date.available2022-06-13T17:11:30Z
dc.date.issued2022-06-20
dc.description12th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-12), Toronto, Canada, June 19-23, 2022en_US
dc.description.abstractBackground: In 2002 the 4-dose 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in Calgary for vaccination of children, followed by the 3-dose 13-valent vaccine (PCV13) in 2010. Methods: We conducted an interrupted time series analysis on incidence of IPD per quarter allowing for change in trends in 2002 and 2010. We included models for IPD overall and age and serotype restricted models. Results: The incidence of PCV7 IPD (all ages) decreased after PCV7 introduction in 2002 (P<0.001) and was sustained after PCV13 introduction in 2010. In children, the incidence of PCV13 (less PCV7 ST) IPD increased in children after PCV7 introduction (P<0.001) and decreased after PCV13 introduction (P=0.002). After PCV7 introduction, overall IPD incidence was lower in children, but not significant, (P=0.054) and was unchanged in adults (P=0.4721). After PCV13 introduction, overall IPD incidence was unchanged in children (P=0.88) and increased in adults (P<0.001). Conclusions: PCV7 IPD has declined in the post-PCV period, but overall IPD had not declined significantly and was increasing in adults prior to the precipitous decline observed in 2021, during the COVID-19 pandemic. PCV13 serotypes, as well as non-vaccine serotypes, continue to cause disease, including outbreaks of serotype 4, 5, and 8. It is unclear whether the change from 4 doses to 3 doses of PCV has reduced overall vaccine effectiveness.en_US
dc.identifier.citationRicketson, L., Kellner, J. D., & CASPER Investigators (2022, June 19-23). Pneumococcal Disease Trends in the Post-Vaccine Era in Calgary, Canada: An Interrupted Time Series Analysis [Poster presentation]. 12th International Symposium on Pneumococci and Pneumococcal Diseases, Toronto, Canada. https://isppd.kenes.com/en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/39825
dc.identifier.urihttp://hdl.handle.net/1880/114737
dc.language.isoengen_US
dc.publisher.departmentCommunity Health Sciencesen_US
dc.publisher.departmentMicrobiology, Immunology & Infectious Diseasesen_US
dc.publisher.departmentPaediatricsen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.subjectpneumococcusen_US
dc.subjectvaccinesen_US
dc.subjectpneumococcal conjugate vaccinesen_US
dc.subjectinterrupted time series analysisen_US
dc.titlePneumococcal Disease Trends in the Post-Vaccine Era in Calgary, Canada: An Interrupted Time Series Analysisen_US
dc.typeconference posteren_US
ucalgary.item.requestcopytrueen_US
ucalgary.scholar.levelFacultyen_US
ucalgary.scholar.levelOtheren_US
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