Assessing Nociception by fMRI of the Human Spinal Cord: A Systematic Review

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dc.contributor.authorKolesar, Tiffany A.
dc.contributor.authorFiest, Kirsten M.
dc.contributor.authorSmith, Stephen D.
dc.contributor.authorKornelsen, Jennifer
dc.date.accessioned2019-01-24T21:11:53Z
dc.date.available2019-01-24T21:11:53Z
dc.date.issued2015
dc.description.abstractOBJECTIVE: To assess the use of fMRI of the spinal cord in measuring noxious stimulation. METHODS: The Scopus, Medline, EMBASE, and Web of Science databases were searched, along with the reference lists of included articles. Two independent reviewers screened abstracts, full-text articles, and extracted data. Original research was included if fMRI of the human spinal cord was used to measure responses to noxious stimulation. RESULTS: Of the 192 abstracts screened, 19 met the search criteria and were divided according to their focus: investigating pain responses (n = 6), methodology (n = 6), spinal cord injury (n = 2), or cognition-pain interactions (n = 5). All but one study appear to have observed activity in ipsilateral and dorsal gray matter regions in response to noxious stimuli, although contralateral or ventral activity was also widely observed. CONCLUSIONS: Although nociception can be investigated using spinal fMRI, establishing reliability, standardizing methodology, and reporting of results will greatly advance this field.
dc.description.grantingagencyHealth Sciences Centre Foundation
dc.description.grantingagencyNatural Sciences and Engineering Research Council of Canada
dc.identifier.citationKolesar, T. A., Fiest, K. M., Smith, S. D., & Kornelsen, J. (2015). Assessing Nociception by Fmri of the Human Spinal Cord: A Systematic Review. Magnetic Resonance Insights, 8s1, MRI.S23556. https://doi.org/10.4137/mri.s23556
dc.identifier.doi10.4137/MRI.S23556
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/35776
dc.identifier.issn1178-623X
dc.identifier.urihttp://hdl.handle.net/1880/109517
dc.publisherSAGE PUBLICATIONS LTD
dc.publisher.departmentCritical Care Medicine
dc.publisher.facultyCumming School of Medicine
dc.publisher.hasversionPublished version
dc.publisher.policyhttps://us.sagepub.com/en-us/nam/faqs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.subjectpain
dc.subjectnociception
dc.subjectfunctional MRI
dc.subjectspinal cord
dc.subjectsystematic review
dc.titleAssessing Nociception by fMRI of the Human Spinal Cord: A Systematic Review
dc.typeReview
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