The Prevalence and Incidence of Frontotemporal Dementia: a Systematic Review

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dc.contributor.authorHogan, David B.
dc.contributor.authorJette, Nathalie
dc.contributor.authorFiest, Kirsten M.
dc.contributor.authorRoberts, Jodie I.
dc.contributor.authorPearson, Dawn
dc.contributor.authorSmith, Eric E.
dc.contributor.authorPamela Roach
dc.contributor.authorKirk, Andrew
dc.contributor.authorPringsheim, Tamara
dc.contributor.authorMaxwell, Colleen J.
dc.date.accessioned2019-01-24T21:11:56Z
dc.date.available2019-01-24T21:11:56Z
dc.date.issued2016
dc.description.abstractBackground Population-based prevalence and incidence studies are essential for understanding the burden of frontotemporal dementia (FTD). Methods The MEDLINE and EMBASE databases were searched to identify population-based publications from 1985 to 2012, addressing the incidence and/or prevalence of FTD. References of included articles and prior systematic reviews were searched for additional studies. Two reviewers screened all abstracts and full-text reviews, abstracted data and performed quality assessments. Results Twenty-six studies were included. Methodological limitations led to wide ranges in the estimates for prevalence (point prevalence 0.01-4.6 per 1000 persons; period prevalence 0.16-31.04 per 1000 persons) and incidence (0.0-0.3 per 1000 person-years). FTD accounted for an average of 2.7% (range 0-9.1%) of all dementia cases among prevalence studies that included subjects 65 and older compared to 10.2% (range 2.8-15.7%) in studies restricted to those aged less than 65. The cumulative numbers of male (373 [52.5%]) and female (338 [47.5%]) cases from studies reporting this information were nearly equal (p=0.18). The behavioural variant FTD (bvFTD) was almost four times as common as the primary progressive aphasias. Conclusions Population-based estimates for the epidemiology of FTD varied widely in the included studies. Refinements in the diagnostic process, possibly by the use of validated biomarkers or limiting case ascertainment to specialty services, are needed to obtain more precise estimates of the prevalence and incidence of FTD.
dc.identifier.citationHogan, D. B., Jetté, N., Fiest, K. M., Roberts, J. I., Pearson, D., Smith, E. E., … Maxwell, C. J. (2016). The Prevalence and Incidence of Frontotemporal Dementia: a Systematic Review. Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques, 43(S1), S96–S109. https://doi.org/10.1017/cjn.2016.25
dc.identifier.doi10.1017/cjn.2016.25
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/35783
dc.identifier.issn0317-1671
dc.identifier.urihttp://hdl.handle.net/1880/109524
dc.publisherCAMBRIDGE UNIV PRESS
dc.publisher.departmentCritical Care Medicine
dc.publisher.facultyCumming School of Medicine
dc.publisher.hasversionPublished version
dc.publisher.policyhttps://www.cambridge.org/core/services/open-access-policies
dc.rights© The Canadian Journal of Neurological Sciences Inc. 2016
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDementia
dc.subjectAlzheimer’s Disease
dc.subjectLewy Body Dementia
dc.subjectFrontotemporal Dementia
dc.subjectsystematic review
dc.subjectmeta-analysis
dc.titleThe Prevalence and Incidence of Frontotemporal Dementia: a Systematic Review
dc.typeReview
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