Control of the proliferation versus meiotic development decision in the C. elegansgermline through regulation of GLD-1 protein accumulation
Date
2003
Journal Title
Journal ISSN
Volume Title
Publisher
The Company of Biologists 2004
Abstract
Maintenance of the stem cell population in the C. elegans
germline requires GLP-1/Notch signaling. We show that
this signaling inhibits the accumulation of the RNA binding
protein GLD-1. In a genetic screen to identify other genes
involved in regulating GLD-1 activity, we identified
mutations in the nos-3 gene, the protein product of which
is similar to the Drosophila translational regulator Nanos.
Our data demonstrate that nos-3 promotes GLD-1
accumulation redundantly with gld-2, and that nos-3
functions genetically downstream or parallel to fbf, an
inhibitor of GLD-1 translation. We show that the GLD-1
accumulation pattern is important in controlling the
proliferation versus meiotic development decision, with low
GLD-1 levels allowing proliferation and increased levels
promoting meiotic entry.
Description
Keywords
Biology
Citation
Dave Hansen, Laura Wilson-Berry, Thanh Dang and Tim Schedl "Control of the proliferation versus meiotic development decision in the C. elegansgermline through regulation of GLD-1 protein accumulation " Development 131, 93-104