Control of the proliferation versus meiotic development decision in the C. elegansgermline through regulation of GLD-1 protein accumulation

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dc.contributor.authorHansen, Dave D.en
dc.contributor.authorWilson-Berry, Lauraen
dc.contributor.authorDang,Thanhen
dc.contributor.authorSchedl, Timen
dc.contributor.departmentBiological Sciencesen
dc.contributor.facultyFaculty of Scienceen
dc.contributor.institutionUniversity of Calgaryen
dc.date.accessioned2006-08-15T16:14:53Z
dc.date.available2006-08-15T16:14:53Z
dc.date.issued2003
dc.description.abstractMaintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the nos-3 gene, the protein product of which is similar to the Drosophila translational regulator Nanos. Our data demonstrate that nos-3 promotes GLD-1 accumulation redundantly with gld-2, and that nos-3 functions genetically downstream or parallel to fbf, an inhibitor of GLD-1 translation. We show that the GLD-1 accumulation pattern is important in controlling the proliferation versus meiotic development decision, with low GLD-1 levels allowing proliferation and increased levels promoting meiotic entry.en
dc.description.refereedyesen
dc.format.extent833927 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationDave Hansen, Laura Wilson-Berry, Thanh Dang and Tim Schedl "Control of the proliferation versus meiotic development decision in the C. elegansgermline through regulation of GLD-1 protein accumulation " Development 131, 93-104en
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/30242
dc.identifier.issn0828-0584
dc.identifier.urihttp://hdl.handle.net/1880/43436
dc.language.isoenen
dc.publisherThe Company of Biologists 2004en
dc.subjectBiologyen
dc.subject.otherGermline developmenten
dc.subject.otherStem cellsen
dc.subject.otherProliferationen
dc.subject.otherTumoren
dc.subject.otherMeiotic entryen
dc.subject.otherNotch signalingen
dc.subject.othergld-1en
dc.subject.othernos-3en
dc.subject.otherglp-1en
dc.titleControl of the proliferation versus meiotic development decision in the C. elegansgermline through regulation of GLD-1 protein accumulationen
dc.typejournal article
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