Association between circadian physical activity patterns and mortality in the UK Biobank

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dc.contributor.authorStein, Michael J.
dc.contributor.authorBaurecht, Hansjörg
dc.contributor.authorSedlmeier, Anja M.
dc.contributor.authorKonzok, Julian
dc.contributor.authorBohmann, Patricia
dc.contributor.authorFontvieille, Emma
dc.contributor.authorPeruchet-Noray, Laia
dc.contributor.authorBowden, Jack
dc.contributor.authorFriedenreich, Christine M.
dc.contributor.authorFervers, Béatrice
dc.contributor.authorFerrari, Pietro
dc.contributor.authorGunter, Marc J.
dc.contributor.authorFreisling, Heinz
dc.contributor.authorLeitzmann, Michael F.
dc.contributor.authorViallon, Vivian
dc.contributor.authorWeber, Andrea
dc.date.accessioned2023-09-03T00:02:48Z
dc.date.available2023-09-03T00:02:48Z
dc.date.issued2023-09-01
dc.date.updated2023-09-03T00:02:48Z
dc.description.abstractAbstract Background The benefit of physical activity (PA) for increasing longevity is well-established, however, the impact of diurnal timing of PA on mortality remains poorly understood. We aimed to derive circadian PA patterns and investigate their associations with all-cause mortality. Methods We used 24 h PA time series from 96,351 UK Biobank participants aged between 42 and 79 years at accelerometry in 2013–2015. Functional principal component analysis (fPCA) was applied to obtain circadian PA patterns. Using multivariable Cox proportional hazard models, we related the loading scores of these fPCs to estimate risk of mortality. Results During 6.9 years of follow-up, 2,850 deaths occurred. Four distinct fPCs accounted for 96% of the variation of the accelerometry data. Using a loading score of zero (i.e., average overall PA during the day) as the reference, a fPC1 score of + 2 (high overall PA) was inversely associated with mortality (Hazard ratio, HR = 0.91; 95% CI: 0.84–0.99), whereas a score of -2 (low overall PA) was associated with higher mortality (1.69; 95% CI: 1.57–1.81; p for non-linearity < 0.001). Significant inverse linear associations with mortality were observed for engaging in midday PA instead of early and late PA (fPC3) (HR for a 1-unit increase 0.88; 95% CI: 0.83–0.93). In contrast, midday and nocturnal PA instead of early and evening PA (fPC4) were positively associated with mortality (HR for a 1-unit increase 1.16; 95% CI: 1.08–1.25). Conclusion Our results suggest that it is less important during which daytime hours one is active but rather, to engage in some level of elevated PA for longevity.
dc.identifier.citationInternational Journal of Behavioral Nutrition and Physical Activity. 2023 Sep 01;20(1):102
dc.identifier.urihttps://doi.org/10.1186/s12966-023-01508-z
dc.identifier.urihttps://hdl.handle.net/1880/116956
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/41800
dc.language.rfc3066en
dc.rights.holderBioMed Central Ltd., part of Springer Nature
dc.titleAssociation between circadian physical activity patterns and mortality in the UK Biobank
dc.typeJournal Article
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