Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

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dc.contributor.authorSartelli, Massimo
dc.contributor.authorAbu-Zidan, Fikri M
dc.contributor.authorLabricciosa, Francesco M
dc.contributor.authorKluger, Yoram
dc.contributor.authorCoccolini, Federico
dc.contributor.authorAnsaloni, Luca
dc.contributor.authorLeppäniemi, Ari
dc.contributor.authorKirkpatrick, Andrew W
dc.contributor.authorTolonen, Matti
dc.contributor.authorTranà, Cristian
dc.contributor.authorRegimbeau, Jean-Marc
dc.contributor.authorHardcastle, Timothy
dc.contributor.authorKoshy, Renol M
dc.contributor.authorAbbas, Ashraf
dc.contributor.authorAday, Ulaş
dc.contributor.authorAdesunkanmi, A. R K
dc.contributor.authorAjibade, Adesina
dc.contributor.authorAkhmeteli, Lali
dc.contributor.authorAkın, Emrah
dc.contributor.authorAkkapulu, Nezih
dc.contributor.authorAlotaibi, Alhenouf
dc.contributor.authorAltintoprak, Fatih
dc.contributor.authorAnyfantakis, Dimitrios
dc.contributor.authorAtanasov, Boyko
dc.contributor.authorAugustin, Goran
dc.contributor.authorAzevedo, Constança
dc.contributor.authorBala, Miklosh
dc.contributor.authorBalalis, Dimitrios
dc.contributor.authorBaraket, Oussama
dc.contributor.authorBaral, Suman
dc.contributor.authorBarkai, Or
dc.contributor.authorBeltran, Marcelo
dc.contributor.authorBini, Roberto
dc.contributor.authorBouliaris, Konstantinos
dc.contributor.authorCaballero, Ana B
dc.contributor.authorCalu, Valentin
dc.contributor.authorCatani, Marco
dc.contributor.authorCeresoli, Marco
dc.contributor.authorCharalampakis, Vasileios
dc.contributor.authorJusoh, Asri C
dc.contributor.authorChiarugi, Massimo
dc.contributor.authorCillara, Nicola
dc.contributor.authorCuesta, Raquel C
dc.contributor.authorCobuccio, Luigi
dc.contributor.authorCocorullo, Gianfranco
dc.contributor.authorColak, Elif
dc.contributor.authorConti, Luigi
dc.contributor.authorCui, Yunfeng
dc.contributor.authorDe Simone, Belinda
dc.contributor.authorDelibegovic, Samir
dc.contributor.authorDemetrashvili, Zaza
dc.contributor.authorDemetriades, Demetrios
dc.contributor.authorDimova, Ana
dc.contributor.authorDogjani, Agron
dc.contributor.authorEnani, Mushira
dc.contributor.authorFarina, Federica
dc.contributor.authorFerrara, Francesco
dc.contributor.authorFoghetti, Domitilla
dc.contributor.authorFontana, Tommaso
dc.contributor.authorFraga, Gustavo P
dc.contributor.authorGachabayov, Mahir
dc.contributor.authorGérard, Grelpois
dc.contributor.authorGhnnam, Wagih
dc.contributor.authorMaurel, Teresa G
dc.contributor.authorGkiokas, Georgios
dc.contributor.authorGomes, Carlos A
dc.contributor.authorGuner, Ali
dc.contributor.authorGupta, Sanjay
dc.contributor.authorHecker, Andreas
dc.contributor.authorHirano, Elcio S
dc.contributor.authorHodonou, Adrien
dc.contributor.authorHutan, Martin
dc.contributor.authorIlaschuk, Igor
dc.contributor.authorIoannidis, Orestis
dc.contributor.authorIsik, Arda
dc.contributor.authorIvakhov, Georgy
dc.contributor.authorJain, Sumita
dc.contributor.authorJokubauskas, Mantas
dc.contributor.authorKaramarkovic, Aleksandar
dc.contributor.authorKaushik, Robin
dc.contributor.authorKenig, Jakub
dc.contributor.authorKhokha, Vladimir
dc.contributor.authorKhokha, Denis
dc.contributor.authorKim, Jae I
dc.contributor.authorKong, Victor
dc.contributor.authorKorkolis, Dimitris
dc.contributor.authorKruger, Vitor F
dc.contributor.authorKshirsagar, Ashok
dc.contributor.authorSimões, Romeo L
dc.contributor.authorLanaia, Andrea
dc.contributor.authorLasithiotakis, Konstantinos
dc.contributor.authorLeão, Pedro
dc.contributor.authorArellano, Miguel L
dc.contributor.authorListle, Holger
dc.contributor.authorLitvin, Andrey
dc.contributor.authorLizarazu Pérez, Aintzane
dc.contributor.authorLopez-Tomassetti Fernandez, Eudaldo
dc.contributor.authorLostoridis, Eftychios
dc.contributor.authorLuppi, Davide
dc.contributor.authorMachain V, Gustavo M
dc.contributor.authorMajor, Piotr
dc.contributor.authorManatakis, Dimitrios
dc.contributor.authorReitz, Marianne M
dc.contributor.authorMarinis, Athanasios
dc.contributor.authorMarrelli, Daniele
dc.contributor.authorMartínez-Pérez, Aleix
dc.contributor.authorMarwah, Sanjay
dc.contributor.authorMcFarlane, Michael
dc.contributor.authorMesic, Mirza
dc.contributor.authorMesina, Cristian
dc.contributor.authorMichalopoulos, Nickos
dc.contributor.authorMisiakos, Evangelos
dc.contributor.authorMoreira, Felipe G
dc.contributor.authorMouaqit, Ouadii
dc.contributor.authorMuhtaroglu, Ali
dc.contributor.authorNaidoo, Noel
dc.contributor.authorNegoi, Ionut
dc.contributor.authorNikitina, Zane
dc.contributor.authorNikolopoulos, Ioannis
dc.contributor.authorNita, Gabriela-Elisa
dc.contributor.authorOcchionorelli, Savino
dc.contributor.authorOlaoye, Iyiade
dc.contributor.authorOrdoñez, Carlos A
dc.contributor.authorOzkan, Zeynep
dc.contributor.authorPal, Ajay
dc.contributor.authorPalini, Gian M
dc.contributor.authorPapageorgiou, Kyriaki
dc.contributor.authorPapagoras, Dimitris
dc.contributor.authorPata, Francesco
dc.contributor.authorPędziwiatr, Michał
dc.contributor.authorPereira, Jorge
dc.contributor.authorPereira Junior, Gerson A
dc.contributor.authorPerrone, Gennaro
dc.contributor.authorPintar, Tadeja
dc.contributor.authorPisarska, Magdalena
dc.contributor.authorPlehutsa, Oleksandr
dc.contributor.authorPodda, Mauro
dc.contributor.authorPoillucci, Gaetano
dc.contributor.authorQuiodettis, Martha
dc.contributor.authorRahim, Tuba
dc.contributor.authorRios-Cruz, Daniel
dc.contributor.authorRodrigues, Gabriel
dc.contributor.authorRozov, Dmytry
dc.contributor.authorSakakushev, Boris
dc.contributor.authorSall, Ibrahima
dc.contributor.authorSazhin, Alexander
dc.contributor.authorSemião, Miguel
dc.contributor.authorSharda, Taanya
dc.contributor.authorShelat, Vishal
dc.contributor.authorSinibaldi, Giovanni
dc.contributor.authorSkicko, Dmitrijs
dc.contributor.authorSkrovina, Matej
dc.contributor.authorStamatiou, Dimitrios
dc.contributor.authorStella, Marco
dc.contributor.authorStrzałka, Marcin
dc.contributor.authorSydorchuk, Ruslan
dc.contributor.authorTeixeira Gonsaga, Ricardo A
dc.contributor.authorTochie, Joel N
dc.contributor.authorTomadze, Gia
dc.contributor.authorUgoletti, Lara
dc.contributor.authorUlrych, Jan
dc.contributor.authorÜmarik, Toomas
dc.contributor.authorUzunoglu, Mustafa Y
dc.contributor.authorVasilescu, Alin
dc.contributor.authorVaz, Osborne
dc.contributor.authorVereczkei, Andras
dc.contributor.authorVlad, Nutu
dc.contributor.authorWalędziak, Maciej
dc.contributor.authorYahya, Ali I
dc.contributor.authorYalkin, Omer
dc.contributor.authorYilmaz, Tonguç U
dc.contributor.authorÜnal, Ali E
dc.contributor.authorYuan, Kuo-Ching
dc.contributor.authorZachariah, Sanoop K
dc.contributor.authorŽilinskas, Justas
dc.contributor.authorZizzo, Maurizio
dc.contributor.authorPattonieri, Vittoria
dc.contributor.authorBaiocchi, Gian L
dc.contributor.authorCatena, Fausto
dc.date.accessioned2019-07-21T00:07:24Z
dc.date.available2019-07-21T00:07:24Z
dc.date.issued2019-07-15
dc.date.updated2019-07-21T00:07:24Z
dc.description.abstractAbstract Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28–66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4–10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0–1, 22.7% for those who had scores of 2–3, 46.8% for those who had scores of 4–5, and 86.7% for those who have scores of 7–8. Conclusions The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.
dc.identifier.citationWorld Journal of Emergency Surgery. 2019 Jul 15;14(1):34
dc.identifier.doihttps://doi.org/10.1186/s13017-019-0253-2
dc.identifier.urihttp://hdl.handle.net/1880/110652
dc.identifier.urihttps://doi.org/10.11575/PRISM/44359
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.titlePhysiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study
dc.typeJournal Article
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