Binocular Sensitivity and Specificity of Screening Tests in Prospective Studies of Paired Organs

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atmire.migration.oldid705
dc.contributor.advisorde Leon, Alexander
dc.contributor.authorPerera, Singappuli
dc.date.accessioned2013-01-28T16:00:22Z
dc.date.available2013-06-15T07:01:47Z
dc.date.issued2013-01-28
dc.date.submitted2013en
dc.description.abstractDiagnostic and screening studies in ophthalmology frequently involve binocular data where pairs of eyes are evaluated, through some diagnostic procedure, for the presence of certain diseases or pathologies. It is usually sufficient in practice that at least one eye is positively diagnosed for the patient to be sent for further and more extensive eye examination. More relevant diagnostic accuracy measures in these cases are therefore the probability of at least one correct positive diagnosis in patients with one or both eyes truly diseased and the probability of two correct negative diagnoses for patients with both eyes truly un-diseased. The former is analogous to sensitivity and the latter to specificity. Predictive values may be similarly re-defined. The thesis proposes these new sensitivity and specificity measures as alternatives to conventional ones for paired binocular binary diagnostic data arising from screening studies with cross-sectional sampling. The measures are defined for flexible models based on copulas and extensions of existing models for correlated binary data. The proposed methodology is illustrated with data from a study on diabetic retinopathy.en_US
dc.identifier.citationPerera, S. (2013). Binocular Sensitivity and Specificity of Screening Tests in Prospective Studies of Paired Organs (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25120en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25120
dc.identifier.urihttp://hdl.handle.net/11023/517
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiostatistics
dc.subjectOphthalmology
dc.subjectStatistics
dc.subject.classificationcopulas, ECCM, ophthalmology, retinopathyen_US
dc.titleBinocular Sensitivity and Specificity of Screening Tests in Prospective Studies of Paired Organs
dc.typemaster thesis
thesis.degree.disciplineMathematics and Statistics
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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