Multi-Regional Investigation of the Relationship between Functional MRI Blood Oxygenation Level Dependent (BOLD) Activation and GABA Concentration

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dc.contributor.authorHarris, Ashley D.
dc.contributor.authorPuts, Nicholaas A.J.
dc.contributor.authorAnderson, Brian A.
dc.contributor.authorYantis, Steven
dc.contributor.authorPekar, James J.
dc.contributor.authorBarker, Peter B.
dc.contributor.authorEdden, Richard A.E.
dc.date.accessioned2021-01-06T20:50:55Z
dc.date.available2021-01-06T20:50:55Z
dc.date.issued2015-02-20
dc.description.abstractSeveral recent studies have reported an inter-individual correlation between regional GABA concentration, as measured by MRS, and the amplitude of the functional blood oxygenation level dependent (BOLD) response in the same region. In this study, we set out to investigate whether this coupling generalizes across cortex. In 18 healthy participants, we performed edited MRS measurements of GABA and BOLD-fMRI experiments using regionally related activation paradigms. Regions and tasks were the: occipital cortex with a visual grating stimulus; auditory cortex with a white noise stimulus; sensorimotor cortex with a finger-tapping task; frontal eye field with a saccade task; and dorsolateral prefrontal cortex with a working memory task. In contrast to the prior literature, no correlation between GABA concentration and BOLD activation was detected in any region. The origin of this discrepancy is not clear. Subtle differences in study design or insufficient power may cause differing results; these and other potential reasons for the discrepant results are discussed. This negative result, although it should be interpreted with caution, has a larger sample size than prior positive results, and suggests that the relationship between GABA and the BOLD response may be more complex than previously thought.
dc.description.grantingagencyOther
dc.identifier.citationHarris, A. D., Puts, N. A. J., Anderson, B. A., Yantis, S., Pekar, J. J., Barker, P. B., & Edden, R. A. E. (2015). Multi-Regional Investigation of the Relationship between Functional MRI Blood Oxygenation Level Dependent (BOLD) Activation and GABA Concentration. PLOS ONE, 10(2), e0117531. https://doi.org/10.1371/journal.pone.0117531
dc.identifier.doi10.1371/journal.pone.0117531
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38524
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1880/112932
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.publisher.hasversionPublisher's version
dc.publisher.policyhttps://plos.org/open-science/why-open-access/
dc.rights© 2015 Harris et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGamma-aminobutyric acid
dc.subjectfunctional magnetic resonance imaging
dc.subjectoccipital lobe
dc.subjectvision
dc.subjectprefrontal cortex
dc.subjectauditory cortex
dc.subjectworking memory
dc.subjecteye movements
dc.titleMulti-Regional Investigation of the Relationship between Functional MRI Blood Oxygenation Level Dependent (BOLD) Activation and GABA Concentration
dc.typejournal article
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