Both Mother and Infant Require a Vitamin D Supplement to Ensure That Infants' Vitamin D Status Meets Current Guidelines

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dc.contributor.authorAghajafari, Fariba
dc.date.accessioned2018-04-18T17:27:21Z
dc.date.available2018-04-18T17:27:21Z
dc.date.issued2018-03-29
dc.description.abstractWe examined the association between maternal vitamin D intake during breastfeeding with their infants' vitamin D status in infants who did or did not receive vitamin D supplements to determine whether infant supplementation was sufficient. Using plasma from a subset of breastfed infants in the APrON (Alberta Pregnant Outcomes and Nutrition) cohort, vitamin D status was measured by liquid chromatography-tandem mass spectrometry. Maternal and infants' dietary data were obtained from APrON's dietary questionnaires. The median maternal vitamin D intake was 665 International Units (IU)/day, while 25% reported intakes below the recommended 400 IU/day. Of the 224 infants in the cohort, 72% were exclusively breastfed, and 90% were receiving vitamin D supplements. Infants' median 25(OH)D was 96.0 nmol/L (interquartile ranges (IQR) 77.6-116.2), and 25% had 25(OH)D < 75 nmol/L. An adjusted linear regression model showed that, with a 100 IU increase in maternal vitamin D intake, infants' 25(OH)D increased by 0.9 nmol/L controlling for race, season, mid-pregnancy maternal 25(OH)D, birthweight, and whether the infant received daily vitamin D supplement (β = 0.008, 95% confidence interval (CI) 0.002, 0.13). These results suggest that, to ensure infant optimal vitamin D status, not only do infants require a supplement, but women also need to meet current recommended vitamin D intake during breastfeeding.en_US
dc.identifier.citationAghajafari, F. (2018). Both Mother and Infant Require a Vitamin D Supplement to Ensure That Infants’ Vitamin D Status Meets Current Guidelines. Nutrients, 10, pp. 429.en_US
dc.identifier.doihttp://dx.doi.org/10.3390/nu10040429en_US
dc.identifier.urihttp://hdl.handle.net/1880/106508
dc.identifier.urihttps://doi.org/10.11575/PRISM/43751
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.publisher.departmentFamily Medicineen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.hasversionPre-printen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleBoth Mother and Infant Require a Vitamin D Supplement to Ensure That Infants' Vitamin D Status Meets Current Guidelinesen_US
dc.typejournal article
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