Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort

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dc.contributor.authorGuzman, Jaime
dc.contributor.authorKerr, Tristan
dc.contributor.authorWard, Leanne M
dc.contributor.authorMa, Jinhui
dc.contributor.authorOen, Kiem
dc.contributor.authorRosenberg, Alan M
dc.contributor.authorFeldman, Brian M
dc.contributor.authorBoire, Gilles
dc.contributor.authorHoughton, Kristin
dc.contributor.authorDancey, Paul
dc.contributor.authorScuccimarri, Rosie
dc.contributor.authorBruns, Alessandra
dc.contributor.authorHuber, Adam M
dc.contributor.authorWatanabe Duffy, Karen
dc.contributor.authorShiff, Natalie J
dc.contributor.authorBerard, Roberta A
dc.contributor.authorLevy, Deborah M
dc.contributor.authorStringer, Elizabeth
dc.contributor.authorMorishita, Kimberly
dc.contributor.authorJohnson, Nicole
dc.contributor.authorCabral, David A
dc.contributor.authorLarché, Maggie
dc.contributor.authorPetty, Ross E
dc.contributor.authorLaxer, Ronald M
dc.contributor.authorSilverman, Earl
dc.contributor.authorMiettunen, Paivi
dc.contributor.authorChetaille, Anne-Laure
dc.contributor.authorHaddad, Elie
dc.contributor.authorSpiegel, Lynn
dc.contributor.authorTurvey, Stuart E
dc.contributor.authorSchmeling, Heinrike
dc.contributor.authorLang, Bianca
dc.contributor.authorEllsworth, Janet
dc.contributor.authorRamsey, Suzanne E
dc.contributor.authorRoth, Johannes
dc.contributor.authorCampillo, Sarah
dc.contributor.authorBenseler, Susanne
dc.contributor.authorChédeville, Gaëlle
dc.contributor.authorSchneider, Rayfel
dc.contributor.authorTse, Shirley M L
dc.contributor.authorBolaria, Roxana
dc.contributor.authorGross, Katherine
dc.contributor.authorFeldman, Debbie
dc.contributor.authorCameron, Bonnie
dc.contributor.authorJurencak, Roman
dc.contributor.authorDorval, Jean
dc.contributor.authorLeBlanc, Claire
dc.contributor.authorSt. Cyr, Claire
dc.contributor.authorGibbon, Michele
dc.contributor.authorYeung, Rae S M
dc.contributor.authorDuffy, Ciarán M
dc.contributor.authorTucker, Lori B
dc.date.accessioned2018-09-26T12:07:08Z
dc.date.available2018-09-26T12:07:08Z
dc.date.issued2017-08-22
dc.date.updated2018-09-26T12:07:07Z
dc.description.abstractAbstract Background With modern treatments, the effect of juvenile idiopathic arthritis (JIA) on growth may be less than previously reported. Our objective was to describe height, weight and body mass index (BMI) development in a contemporary JIA inception cohort. Methods Canadian children newly-diagnosed with JIA 2005–2010 had weight and height measurements every 6 months for 2 years, then yearly up to 5 years. These measurements were used to calculate mean age- and sex-standardized Z-scores, and estimate prevalence and cumulative incidence of growth impairments, and the impact of disease activity and corticosteroids on growth. Results One thousand one hundred forty seven children were followed for median 35.5 months. Mean Z-scores, and the point prevalence of short stature (height < 2.5th percentile, 2.5% to 3.4%) and obesity (BMI > 95th percentile, 15.8% to 16.4%) remained unchanged in the whole cohort. Thirty-three children (2.9%) developed new-onset short stature, while 27 (2.4%) developed tall stature (>97.5th percentile). Children with systemic arthritis (n = 77) had an estimated 3-year cumulative incidence of 9.3% (95%CI: 4.3–19.7) for new-onset short stature and 34.4% (23–49.4) for obesity. Most children (81.7%) received no systemic corticosteroids, but 1 mg/Kg/day prednisone-equivalent maintained for 6 months corresponded to a drop of 0.64 height Z-scores (0.56–0.82) and an increase of 0.74 BMI Z-scores (0.56–0.92). An increase of 1 in the 10-cm physician global assessment of disease activity maintained for 6 months corresponded to a drop of 0.01 height Z-scores (0–0.02). Conclusions Most children in this modern JIA cohort grew and gained weight as children in the general population. About 1 in 10 children who had systemic arthritis, uncontrolled disease and/or prolonged corticosteroid use, had increased risk of growth impairment.
dc.identifier.citationPediatric Rheumatology. 2017 Aug 22;15(1):68
dc.identifier.doihttps://doi.org/10.1186/s12969-017-0196-7
dc.identifier.urihttp://hdl.handle.net/1880/107989
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.titleGrowth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort
dc.typeJournal Article
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