The International/Canadian Hereditary Angioedema Guideline

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dc.contributor.authorBetschel, Stephen
dc.contributor.authorBadiou, Jacquie
dc.contributor.authorBinkley, Karen
dc.contributor.authorBorici-Mazi, Rozita
dc.contributor.authorHébert, Jacques
dc.contributor.authorKanani, Amin
dc.contributor.authorKeith, Paul
dc.contributor.authorLacuesta, Gina
dc.contributor.authorWaserman, Susan
dc.contributor.authorYang, Bill
dc.contributor.authorAygören-Pürsün, Emel
dc.contributor.authorBernstein, Jonathan
dc.contributor.authorBork, Konrad
dc.contributor.authorCaballero, Teresa
dc.contributor.authorCicardi, Marco
dc.contributor.authorCraig, Timothy
dc.contributor.authorFarkas, Henriette
dc.contributor.authorGrumach, Anete
dc.contributor.authorKatelaris, Connie
dc.contributor.authorLonghurst, Hilary
dc.contributor.authorRiedl, Marc
dc.contributor.authorZuraw, Bruce
dc.contributor.authorBerger, Magdelena
dc.contributor.authorBoursiquot, Jean-Nicolas
dc.contributor.authorBoysen, Henrik
dc.contributor.authorCastaldo, Anthony
dc.contributor.authorChapdelaine, Hugo
dc.contributor.authorConnors, Lori
dc.contributor.authorFu, Lisa
dc.contributor.authorGoodyear, Dawn
dc.contributor.authorHaynes, Alison
dc.contributor.authorKamra, Palinder
dc.contributor.authorKim, Harold
dc.contributor.authorLang-Robertson, Kelly
dc.contributor.authorLeith, Eric
dc.contributor.authorMcCusker, Christine
dc.contributor.authorMoote, Bill
dc.contributor.authorO’Keefe, Andrew
dc.contributor.authorOthman, Ibraheem
dc.contributor.authorPoon, Man-Chiu
dc.contributor.authorRitchie, Bruce
dc.contributor.authorSt-Pierre, Charles
dc.contributor.authorStark, Donald
dc.contributor.authorTsai, Ellie
dc.date.accessioned2019-12-01T01:02:40Z
dc.date.available2019-12-01T01:02:40Z
dc.date.issued2019-11-25
dc.date.updated2019-12-01T01:02:39Z
dc.description.abstractAbstract This is an update to the 2014 Canadian Hereditary Angioedema Guideline with an expanded scope to include the management of hereditary angioedema (HAE) patients worldwide. It is a collaboration of Canadian and international HAE experts and patient groups led by the Canadian Hereditary Angioedema Network. The objective of this guideline is to provide evidence-based recommendations, using the GRADE system, for the management of patients with HAE. This includes the treatment of attacks, short-term prophylaxis, long-term prophylaxis, and recommendations for self-administration, individualized therapy, quality of life, and comprehensive care. New to the 2019 version of this guideline are sections covering the diagnosis and recommended therapies for acute treatment in HAE patients with normal C1-INH, as well as sections on pregnant and paediatric patients, patient associations and an HAE registry. Hereditary angioedema results in random and often unpredictable attacks of painful swelling typically affecting the extremities, bowel mucosa, genitals, face and upper airway. Attacks are associated with significant functional impairment, decreased health-related quality of life, and mortality in the case of laryngeal attacks. Caring for patients with HAE can be challenging due to the complexity of this disease. The care of patients with HAE in Canada, as in many countries, continues to be neither optimal nor uniform. It lags behind some other countries where there are more organized models for HAE management, and greater availability of additional licensed therapeutic options. It is anticipated that providing this guideline to caregivers, policy makers, patients, and advocates will not only optimize the management of HAE, but also promote the importance of individualized care. The primary target users of this guideline are healthcare providers who are managing patients with HAE. Other healthcare providers who may use this guideline are emergency and intensive care physicians, primary care physicians, gastroenterologists, dentists, otolaryngologists, paediatricians, and gynaecologists who will encounter patients with HAE and need to be aware of this condition. Hospital administrators, insurers and policy makers may also find this guideline helpful.
dc.identifier.citationAllergy, Asthma & Clinical Immunology. 2019 Nov 25;15(1):72
dc.identifier.doihttps://doi.org/10.1186/s13223-019-0376-8
dc.identifier.urihttp://hdl.handle.net/1880/111271
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.titleThe International/Canadian Hereditary Angioedema Guideline
dc.typeJournal Article
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