Characterizing Cortical Atrophy in Patients with Cerebral Amyloid Angiopathy: A Cross-Sectional and Longitudinal Analysis
Date
2019-05-15
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Abstract
This study investigated cortical thickness in participants with Cerebral Amyloid Angiopathy (CAA) cross-sectionally and longitudinally, as well as its relationship with cognition and other markers of CAA pathology using Magnetic Resonance Imaging (MRI). CAA participants had lower global thickness compared to healthy controls (HC) (p=0.03) and greater global thickness compared to a group of participants with Alzheimer’s Disease (AD) (p=0.001). Cross-sectionally in CAA, an association was found between thickness and memory scores (p=0.01) and lower thickness and higher white matter hyperintensity volume (WMH) (p=0.04). Longitudinally, CAA participants had a greater rate of thinning compared to HC (p=0.008). No associations were found between thinning over time and cognition and WMH volume at baseline in CAA. Distinct differences from HC and AD suggest cortical thickness is a possible biomarker of CAA pathology and a potential therapeutic target.
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Keywords
Cerebral Amyloid Angiopathy, Cortical Thickness, Alzheimer's Disease, Brain, Atrophy, Magnetic Resonance Imaging
Citation
Subotic, A. (2019). Characterizing Cortical Atrophy in Patients with Cerebral Amyloid Angiopathy: A Cross-Sectional and Longitudinal Analysis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.