Characterizing Cortical Atrophy in Patients with Cerebral Amyloid Angiopathy: A Cross-Sectional and Longitudinal Analysis

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dc.contributor.advisorSmith, Eric Edward
dc.contributor.authorSubotic, Arsenije
dc.contributor.committeememberPike, G. Bruce
dc.contributor.committeememberIsmail, Zahinoor
dc.date2019-11
dc.date.accessioned2019-05-16T22:41:31Z
dc.date.available2019-05-16T22:41:31Z
dc.date.issued2019-05-15
dc.description.abstractThis study investigated cortical thickness in participants with Cerebral Amyloid Angiopathy (CAA) cross-sectionally and longitudinally, as well as its relationship with cognition and other markers of CAA pathology using Magnetic Resonance Imaging (MRI). CAA participants had lower global thickness compared to healthy controls (HC) (p=0.03) and greater global thickness compared to a group of participants with Alzheimer’s Disease (AD) (p=0.001). Cross-sectionally in CAA, an association was found between thickness and memory scores (p=0.01) and lower thickness and higher white matter hyperintensity volume (WMH) (p=0.04). Longitudinally, CAA participants had a greater rate of thinning compared to HC (p=0.008). No associations were found between thinning over time and cognition and WMH volume at baseline in CAA. Distinct differences from HC and AD suggest cortical thickness is a possible biomarker of CAA pathology and a potential therapeutic target.en_US
dc.identifier.citationSubotic, A. (2019). Characterizing Cortical Atrophy in Patients with Cerebral Amyloid Angiopathy: A Cross-Sectional and Longitudinal Analysis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/36539
dc.identifier.urihttp://hdl.handle.net/1880/110367
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectCerebral Amyloid Angiopathyen_US
dc.subjectCortical Thicknessen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectBrainen_US
dc.subjectAtrophyen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subject.classificationEducation--Healthen_US
dc.subject.classificationEducation--Sciencesen_US
dc.subject.classificationBiophysics--Medicalen_US
dc.subject.classificationPsychology--Clinicalen_US
dc.titleCharacterizing Cortical Atrophy in Patients with Cerebral Amyloid Angiopathy: A Cross-Sectional and Longitudinal Analysisen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Medical Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrue
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