The Effect of Glucagon-Like Peptide-2 Receptor Agonists on Colonic Anastomotic Wound Healing

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dc.contributor.authorRedstone, Heather A.
dc.contributor.authorBuie, William D.
dc.contributor.authorHart, David A.
dc.contributor.authorWallace, Laurie
dc.contributor.authorHornby, Pamela J.
dc.contributor.authorSague, Sarah
dc.contributor.authorHolst, Jen J.
dc.contributor.authorSigalet, David L.
dc.date.accessioned2018-09-27T12:04:20Z
dc.date.available2018-09-27T12:04:20Z
dc.date.issued2010-10-04
dc.date.updated2018-09-27T12:04:20Z
dc.description.abstractBackground. Glucagon-like peptide 2 (GLP-2) is an intestinal specific trophic hormone, with therapeutic potential; the effects on intestinal healing are unknown. We used a rat model of colonic healing, under normoxic, and stress (hypoxic) conditions to examine the effect of GLP-2 on intestinal healing. Methods. Following colonic transection and reanastomosis, animals were randomized to one of six groups (/group): controls, native GLP-2, long-acting GLP-2 (GLP-2- MIMETIBODY, GLP-2-MMB), animals were housed under normoxic or hypoxic (11%  ) conditions. Animals were studied five days post-operation for anastomotic strength and wound characteristics. Results. Anastomotic bursting pressure was unchanged by GLP-2 or GLP-2-MMB in normoxic or hypoxic animals; both treatments increased crypt cell proliferation. Wound IL-1 increased with GLP-2; IFN with GLP-2 and GLP-2-MMB. IL-10 and TGF- were decreased; Type I collagen mRNA expression increased in hypoxic animals while Type III collagen was reduced with both GLP-2 agonists. GLP-2 MMB, but not native GLP-2 increased TIMP 1-3 mRNA levels in hypoxia. Conclusions. The effects on CCP, cytokines and wound healing were similar for both GLP-2 agonists under normoxic and hypoxic conditions; anastomotic strength was not affected. This suggests that GLP-2 (or agonists) could be safely used peri-operatively; direct studies will be required.
dc.description.versionPeer Reviewed
dc.identifier.citationHeather A. Redstone, William D. Buie, David A. Hart, et al., “The Effect of Glucagon-Like Peptide-2 Receptor Agonists on Colonic Anastomotic Wound Healing,” Gastroenterology Research and Practice, vol. 2010, Article ID 672453, 12 pages, 2010. doi:10.1155/2010/672453
dc.identifier.doihttps://doi.org/10.1155/2010/672453
dc.identifier.urihttp://hdl.handle.net/1880/108458
dc.identifier.urihttps://doi.org/10.11575/PRISM/44677
dc.language.rfc3066en
dc.rights.holderCopyright © 2010 Heather A. Redstone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleThe Effect of Glucagon-Like Peptide-2 Receptor Agonists on Colonic Anastomotic Wound Healing
dc.typeJournal Article
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