Genetic boundaries delineate the potential human pathogen Salmonella bongori into discrete lineages: divergence and speciation

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dc.contributor.authorWang, Xiaoyu
dc.contributor.authorZhu, Songling
dc.contributor.authorZhao, Jian-Hua
dc.contributor.authorBao, Hong-Xia
dc.contributor.authorLiu, Huidi
dc.contributor.authorDing, Tie-Min
dc.contributor.authorLiu, Gui-Rong
dc.contributor.authorLi, Yong-Guo
dc.contributor.authorJohnston, Randal N
dc.contributor.authorCao, Feng-Lin
dc.contributor.authorTang, Le
dc.contributor.authorLiu, Shu-Lin
dc.date.accessioned2019-12-08T01:05:06Z
dc.date.available2019-12-08T01:05:06Z
dc.date.issued2019-12-04
dc.date.updated2019-12-08T01:05:05Z
dc.description.abstractAbstract Background Salmonella bongori infect mainly cold-blooded hosts, but infections by S. bongori in warm-blooded hosts have been reported. We hypothesized that S. bongori might have diverged into distinct phylogenetic lineages, with some being able to infect warm-blooded hosts. Results To inspect the divergence status of S. bongori, we first completely sequenced the parakeet isolate RKS3044 and compared it with other sequenced S. bongori strains. We found that RKS3044 contained a novel T6SS encoded in a pathogenicity island-like structure, in addition to a T6SS encoded in SPI-22, which is common to all S. bongori strains so far reported. This novel T6SS resembled the SPI-19 T6SS of the warm-blooded host infecting Salmonella Subgroup I lineages. Genomic sequence comparisons revealed different genomic sequence amelioration events among the S. bongori strains, including a unique CTAG tetranucleotide degeneration pattern in RKS3044, suggesting non-overlapping gene pools between RKS3044 and other S. bongori lineages/strains leading to their independent accumulation of genomic variations. We further proved the existence of a clear-cut genetic boundary between RKS3044 and the other S. bongori lineages/strains analyzed in this study. Conclusions The warm-blooded host-infecting S. bongori strain RKS3044 has diverged with distinct genomic features from other S. bongori strains, including a novel T6SS encoded in a previously not reported pathogenicity island-like structure and a unique genomic sequence degeneration pattern. These findings alert cautions about the emergence of new pathogens originating from non-pathogenic ancestors by acquiring specific pathogenic traits.
dc.identifier.citationBMC Genomics. 2019 Dec 04;20(1):930
dc.identifier.doihttps://doi.org/10.1186/s12864-019-6259-z
dc.identifier.urihttp://hdl.handle.net/1880/111317
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.titleGenetic boundaries delineate the potential human pathogen Salmonella bongori into discrete lineages: divergence and speciation
dc.typeJournal Article
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